Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER Database
Objectives. We aimed to establish an effective machine learning (ML) model for predicting the risk of distant metastasis (DM) in medullary thyroid carcinoma (MTC). Methods. Demographic data of MTC patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database of the Nat...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2023/9965578 |
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| author | Zhen-Tian Guo Kun Tian Xi-Yuan Xie Yu-Hang Zhang De-Bao Fang |
| author_facet | Zhen-Tian Guo Kun Tian Xi-Yuan Xie Yu-Hang Zhang De-Bao Fang |
| author_sort | Zhen-Tian Guo |
| collection | DOAJ |
| description | Objectives. We aimed to establish an effective machine learning (ML) model for predicting the risk of distant metastasis (DM) in medullary thyroid carcinoma (MTC). Methods. Demographic data of MTC patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database of the National Institutes of Health between 2004 and 2015 to develop six ML algorithm models. Models were evaluated based on accuracy, precision, recall rate, F1-score, and area under the receiver operating characteristic curve (AUC). The association between clinicopathological characteristics and target variables was interpreted. Analyses were performed using traditional logistic regression (LR). Results. In total, 2049 patients were included and 138 developed DM. Multivariable LR showed that age, sex, tumor size, extrathyroidal extension, and lymph node metastasis were predictive features for DM in MTC. Among the six ML models, the random forest (RF) had the best predictability in assessing the risk of DM in MTC, with an accuracy, precision, recall rate, F1-score, and AUC higher than those of the traditional binary LR model. Conclusion. RF was superior to traditional LR in predicting the risk of DM in MTC and can provide a valuable reference for clinicians in decision-making. |
| format | Article |
| id | doaj-art-a808a78939334b789a8ffa2cf60a7320 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a808a78939334b789a8ffa2cf60a73202025-02-03T06:45:38ZengWileyInternational Journal of Endocrinology1687-83452023-01-01202310.1155/2023/9965578Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER DatabaseZhen-Tian Guo0Kun Tian1Xi-Yuan Xie2Yu-Hang Zhang3De-Bao Fang4Department of General SurgeryDepartment of General SurgeryFujian Provincial HospitalMudanjiang Medical UniversityHefei National Laboratory for Physical Sciences at MicroscaleObjectives. We aimed to establish an effective machine learning (ML) model for predicting the risk of distant metastasis (DM) in medullary thyroid carcinoma (MTC). Methods. Demographic data of MTC patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database of the National Institutes of Health between 2004 and 2015 to develop six ML algorithm models. Models were evaluated based on accuracy, precision, recall rate, F1-score, and area under the receiver operating characteristic curve (AUC). The association between clinicopathological characteristics and target variables was interpreted. Analyses were performed using traditional logistic regression (LR). Results. In total, 2049 patients were included and 138 developed DM. Multivariable LR showed that age, sex, tumor size, extrathyroidal extension, and lymph node metastasis were predictive features for DM in MTC. Among the six ML models, the random forest (RF) had the best predictability in assessing the risk of DM in MTC, with an accuracy, precision, recall rate, F1-score, and AUC higher than those of the traditional binary LR model. Conclusion. RF was superior to traditional LR in predicting the risk of DM in MTC and can provide a valuable reference for clinicians in decision-making.http://dx.doi.org/10.1155/2023/9965578 |
| spellingShingle | Zhen-Tian Guo Kun Tian Xi-Yuan Xie Yu-Hang Zhang De-Bao Fang Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER Database International Journal of Endocrinology |
| title | Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER Database |
| title_full | Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER Database |
| title_fullStr | Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER Database |
| title_full_unstemmed | Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER Database |
| title_short | Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER Database |
| title_sort | machine learning for predicting distant metastasis of medullary thyroid carcinoma using the seer database |
| url | http://dx.doi.org/10.1155/2023/9965578 |
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