Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome
Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2022/3851225 |
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| author | Laura Parada-Niño Luisa Fernanda Castillo-León Adrien Morel |
| author_facet | Laura Parada-Niño Luisa Fernanda Castillo-León Adrien Morel |
| author_sort | Laura Parada-Niño |
| collection | DOAJ |
| description | Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. These studies help us better understand the disease to advance new treatment strategies. |
| format | Article |
| id | doaj-art-a80377103fb3413a8215838b92b11f0e |
| institution | Kabale University |
| issn | 2090-2735 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-a80377103fb3413a8215838b92b11f0e2025-02-03T00:59:35ZengWileyJournal of Pregnancy2090-27352022-01-01202210.1155/2022/3851225Preeclampsia, Natural History, Genes, and miRNAs Associated with the SyndromeLaura Parada-Niño0Luisa Fernanda Castillo-León1Adrien Morel2Center for Research in Genetics and Genomics-CIGGURCenter for Research in Genetics and Genomics-CIGGURCenter for Research in Genetics and Genomics-CIGGURPreeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. These studies help us better understand the disease to advance new treatment strategies.http://dx.doi.org/10.1155/2022/3851225 |
| spellingShingle | Laura Parada-Niño Luisa Fernanda Castillo-León Adrien Morel Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome Journal of Pregnancy |
| title | Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome |
| title_full | Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome |
| title_fullStr | Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome |
| title_full_unstemmed | Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome |
| title_short | Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome |
| title_sort | preeclampsia natural history genes and mirnas associated with the syndrome |
| url | http://dx.doi.org/10.1155/2022/3851225 |
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