Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polarization

Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polarization

Abstract Introduction Bone marrow-derived mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) are widely used for therapeutic purposes in preclinical studies. However, their utility in treating diabetes-associated atherosclerosis remains largely unexplored. Here, we aimed to characterize...

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Bibliographic Details
Main Authors: Libo Liu, Ziyu An, Huan Zhang, Xueqi Wan, Xin Zhao, Xueyao Yang, Jinfan Tian, Xiantao Song
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cardiovascular Diabetology
Subjects:
Diabetes
Atherosclerosis
Bone marrow mesenchymal stem cell-derived extracellular vesicles
Autophagy
Macrophage polarization
AMPK/mTOR pathway
Online Access:https://doi.org/10.1186/s12933-025-02603-0
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