Precision-engineered mRNA vaccines: antigen design, structural optimization, and programmable delivery for emerging pathogens

Precision-engineered mRNA vaccines: antigen design, structural optimization, and programmable delivery for emerging pathogens

Abstract The rapid evolution of pathogen threats and pandemic risks has intensified the demand for adaptable vaccine platforms with rapid design-to-clinical timelines. The success of BNT162b2 and mRNA-1273 in controlling COVID-19 has led to unprecedented changes in vaccine development. Compared with...

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Bibliographic Details
Main Authors: Yanyu Zhang, Junchi Li, Zihan Wang, Yu Kuang, Songli Li, Xiaojia Wang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Animal Diseases
Subjects:
Infectious disease
MRNA vaccine
Immunogenicity
Optimization strategy
Online Access:https://doi.org/10.1186/s44149-025-00186-7
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