Evaluation of ultrasonography and plethysmography in detecting blood loss and volume replacement in a platelet apheresis model
Background: Rapid, reproducible, and noninvasive diagnostic methods like Ultrasonography (US) and plethysmographic measurements such as the perfusion index (PI) and pleth variablity index (PVI) have great potential value for emergency trauma cases in which blood loss needs to be recognized quickly a...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025002294 |
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| author | Kıvanç KARAMAN Furkan Çağrı OĞUZLAR Sinan SİTEMBÖLÜKBAŞI Erşan KAYA |
| author_facet | Kıvanç KARAMAN Furkan Çağrı OĞUZLAR Sinan SİTEMBÖLÜKBAŞI Erşan KAYA |
| author_sort | Kıvanç KARAMAN |
| collection | DOAJ |
| description | Background: Rapid, reproducible, and noninvasive diagnostic methods like Ultrasonography (US) and plethysmographic measurements such as the perfusion index (PI) and pleth variablity index (PVI) have great potential value for emergency trauma cases in which blood loss needs to be recognized quickly and accurately. Objectives: We planned this study to evaluate the utility of US, PI, and PVI in detecting early-stage hemorrhage and mimicking volume replacement using a platelet apheresis model. Methods: This prospective, observational study included 46 healthy platelet apheresis volunteers who met inclusion criteria. Both of US measurements of Vena Cava Inferior (VCImin, VCImax, and VCIcı) and plethysmographic measurements were performed in three time period (before apheresis, after whole blood was collected, and after blood components except platelets were returned to donors). Results: Among the total 308 platelet apheresis, 46 male volunteers met inclusion criteria and consented to participate in the study. Of these 46 male volunteers, nine declined to have US measurements. After a mean blood loss of 440 ml in the first phase of apheresis, IVCmax decreased significantly, while pulse increased (p = 0.021 and p < 0.001, respectively). After the third phase of apheresis, which simulated volume replacement, IVCmin and IVCmax increased significantly, while pulse decreased (p = 0.003, p < 0.001, and p < 0.001, respectively). Conclusion: Per this platelet apheresis model, IVCmax is a diagnostic marker for both early-stage blood loss of less than 500 ml and volume replacement. |
| format | Article |
| id | doaj-art-a7f655da692644deb5c085ee4b19b029 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-a7f655da692644deb5c085ee4b19b0292025-02-02T05:28:22ZengElsevierHeliyon2405-84402025-01-01112e41849Evaluation of ultrasonography and plethysmography in detecting blood loss and volume replacement in a platelet apheresis modelKıvanç KARAMAN0Furkan Çağrı OĞUZLAR1Sinan SİTEMBÖLÜKBAŞI2Erşan KAYA3Medical Faculty of Mugla Sitki Kocman University, Emergency Medicine Department, Muğla, TurkeyMedical Faculty of Suleyman Demirel University, Emergency Medicine Department, Isparta, Turkey; Corresponding author. 32260, Isparta, Turkey.Simav Doc. Dr. İsmail Karakuyu State Hospital, Kütahya, TurkeyMedical Faculty of Suleyman Demirel University, Blood Transfusion Center, TurkeyBackground: Rapid, reproducible, and noninvasive diagnostic methods like Ultrasonography (US) and plethysmographic measurements such as the perfusion index (PI) and pleth variablity index (PVI) have great potential value for emergency trauma cases in which blood loss needs to be recognized quickly and accurately. Objectives: We planned this study to evaluate the utility of US, PI, and PVI in detecting early-stage hemorrhage and mimicking volume replacement using a platelet apheresis model. Methods: This prospective, observational study included 46 healthy platelet apheresis volunteers who met inclusion criteria. Both of US measurements of Vena Cava Inferior (VCImin, VCImax, and VCIcı) and plethysmographic measurements were performed in three time period (before apheresis, after whole blood was collected, and after blood components except platelets were returned to donors). Results: Among the total 308 platelet apheresis, 46 male volunteers met inclusion criteria and consented to participate in the study. Of these 46 male volunteers, nine declined to have US measurements. After a mean blood loss of 440 ml in the first phase of apheresis, IVCmax decreased significantly, while pulse increased (p = 0.021 and p < 0.001, respectively). After the third phase of apheresis, which simulated volume replacement, IVCmin and IVCmax increased significantly, while pulse decreased (p = 0.003, p < 0.001, and p < 0.001, respectively). Conclusion: Per this platelet apheresis model, IVCmax is a diagnostic marker for both early-stage blood loss of less than 500 ml and volume replacement.http://www.sciencedirect.com/science/article/pii/S2405844025002294HemorrhagePerfusion indexPleth variability indexUltrasonographyVena cava inferior |
| spellingShingle | Kıvanç KARAMAN Furkan Çağrı OĞUZLAR Sinan SİTEMBÖLÜKBAŞI Erşan KAYA Evaluation of ultrasonography and plethysmography in detecting blood loss and volume replacement in a platelet apheresis model Heliyon Hemorrhage Perfusion index Pleth variability index Ultrasonography Vena cava inferior |
| title | Evaluation of ultrasonography and plethysmography in detecting blood loss and volume replacement in a platelet apheresis model |
| title_full | Evaluation of ultrasonography and plethysmography in detecting blood loss and volume replacement in a platelet apheresis model |
| title_fullStr | Evaluation of ultrasonography and plethysmography in detecting blood loss and volume replacement in a platelet apheresis model |
| title_full_unstemmed | Evaluation of ultrasonography and plethysmography in detecting blood loss and volume replacement in a platelet apheresis model |
| title_short | Evaluation of ultrasonography and plethysmography in detecting blood loss and volume replacement in a platelet apheresis model |
| title_sort | evaluation of ultrasonography and plethysmography in detecting blood loss and volume replacement in a platelet apheresis model |
| topic | Hemorrhage Perfusion index Pleth variability index Ultrasonography Vena cava inferior |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025002294 |
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