Metal-phenolic encapsulation of carbon monoxide releasing molecule for enhanced gas therapy of periodontitis
Periodontitis is an infectious disease caused by plaque-associated microorganisms. The condition is characterized by the activation of oxidative stress and immune responses, which contribute to tissue destruction. Carbon monoxide (CO)-based gas therapy, utilizing CO releasing molecules (CORMs), pres...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-10-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425007835 |
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| Summary: | Periodontitis is an infectious disease caused by plaque-associated microorganisms. The condition is characterized by the activation of oxidative stress and immune responses, which contribute to tissue destruction. Carbon monoxide (CO)-based gas therapy, utilizing CO releasing molecules (CORMs), presents a promising therapeutic strategy; however, its efficacy is constrained by the short half-life and limited cellular uptake of CORMs. In this study, metal-phenolic networks (MPN) were employed as a carrier to stabilize CORMs via metal-ligand coordination, thereby forming a nanocomplex designated as CO@MPN. This nanocomplex demonstrated effective scavenging of reactive oxygen species (ROS) and exhibited ROS-responsive CO release. Following phagocytosis by macrophages, CO@MPN significantly decreased intracellular ROS levels, reduced the production of inflammatory factors in lipopolysaccharide (LPS)-stimulated macrophages, facilitated macrophage polarization towards the anti-inflammatory M2 phenotype, and activated heme oxygenase-1 (HO-1) to further attenuate inflammation. In murine models of experimental periodontitis, CO@MPN significantly inhibited inflammatory bone loss and exerted macrophage-regulating effects. The findings underscore the potential of ROS-responsive CO gas therapy as a promising strategy for the treatment of periodontitis and the management of other inflammatory diseases. |
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| ISSN: | 2590-0064 |