Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for the mother and her child. An effective therapeutic that can reduce the incidence of GDM and improve long-term outcomes is a major research priority and is very important for public health. Unfortunately, des...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/1424-8247/18/1/41 |
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| author | Katarzyna Zgutka Marta Tkacz Marta Grabowska Wioletta Mikołajek-Bedner Maciej Tarnowski |
| author_facet | Katarzyna Zgutka Marta Tkacz Marta Grabowska Wioletta Mikołajek-Bedner Maciej Tarnowski |
| author_sort | Katarzyna Zgutka |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for the mother and her child. An effective therapeutic that can reduce the incidence of GDM and improve long-term outcomes is a major research priority and is very important for public health. Unfortunately, despite numerous studies, the molecular mechanisms underlying GDM are not fully defined and require further study. Chronic low-grade inflammation, oxidative stress, and insulin resistance are central features of pregnancies complicated by GDM. There is evidence of the involvement of sirtuins, which are NAD+-dependent histone deacetylases, in energy metabolism and inflammation. Taking these facts into consideration, the role of sirtuins in the pathomechanism of GDM will be discussed. |
| format | Article |
| id | doaj-art-a7d29dddae09458d8bfb10dfc419b137 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-a7d29dddae09458d8bfb10dfc419b1372025-01-24T13:45:07ZengMDPI AGPharmaceuticals1424-82472025-01-011814110.3390/ph18010041Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes MellitusKatarzyna Zgutka0Marta Tkacz1Marta Grabowska2Wioletta Mikołajek-Bedner3Maciej Tarnowski4Department of Physiology in Health Sciences, Faculty of Health Sciences, Pomeranian Medical University, 70-210 Szczecin, PolandDepartment of Physiology in Health Sciences, Faculty of Health Sciences, Pomeranian Medical University, 70-210 Szczecin, PolandDepartment of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University, 71-210 Szczecin, PolandDepartment of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandDepartment of Physiology in Health Sciences, Faculty of Health Sciences, Pomeranian Medical University, 70-210 Szczecin, PolandGestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for the mother and her child. An effective therapeutic that can reduce the incidence of GDM and improve long-term outcomes is a major research priority and is very important for public health. Unfortunately, despite numerous studies, the molecular mechanisms underlying GDM are not fully defined and require further study. Chronic low-grade inflammation, oxidative stress, and insulin resistance are central features of pregnancies complicated by GDM. There is evidence of the involvement of sirtuins, which are NAD+-dependent histone deacetylases, in energy metabolism and inflammation. Taking these facts into consideration, the role of sirtuins in the pathomechanism of GDM will be discussed.https://www.mdpi.com/1424-8247/18/1/41sirtuinspregnancygestational diabetesinflammation |
| spellingShingle | Katarzyna Zgutka Marta Tkacz Marta Grabowska Wioletta Mikołajek-Bedner Maciej Tarnowski Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus Pharmaceuticals sirtuins pregnancy gestational diabetes inflammation |
| title | Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus |
| title_full | Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus |
| title_fullStr | Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus |
| title_full_unstemmed | Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus |
| title_short | Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus |
| title_sort | sirtuins and their implications in the physiopathology of gestational diabetes mellitus |
| topic | sirtuins pregnancy gestational diabetes inflammation |
| url | https://www.mdpi.com/1424-8247/18/1/41 |
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