Added value of dual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT in postoperative follow-up of colorectal cancer
ObjectiveTo assess the added value of dual-phase 99mTc-HYNIC-FAPI-04 single-photon emission computed tomography/computed tomography (SPECT/CT) compared with single-phase imaging in postoperative follow-up of colorectal cancer (CRC).MethodsEarly and delayed 99mTc-HYNIC-FAPI-04 SPECT/CT imaging were u...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1500273/full |
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| author | Donghua Sun Yan Liu Renhua Hou Jianan Li Ye Peng Yingqiu Wang |
| author_facet | Donghua Sun Yan Liu Renhua Hou Jianan Li Ye Peng Yingqiu Wang |
| author_sort | Donghua Sun |
| collection | DOAJ |
| description | ObjectiveTo assess the added value of dual-phase 99mTc-HYNIC-FAPI-04 single-photon emission computed tomography/computed tomography (SPECT/CT) compared with single-phase imaging in postoperative follow-up of colorectal cancer (CRC).MethodsEarly and delayed 99mTc-HYNIC-FAPI-04 SPECT/CT imaging were undertaken in 21 patients with CRC after surgery. The mean radioactivity count of the lesion site and abdominal aorta in secondary imaging was delineated and measured. The early and delayed target background ratio (TBR) and retention index (RI) were calculated, respectively. The results of biopsy or postoperative pathology, clinical and imaging follow-up were used as the “gold standard” of tumor metastasis. Lesions were divided into “benign” and “malignant” groups. The uptake rate and metabolic rate of 99mTc-HYNIC-FAPI-04 in the two groups were observed. The diagnostic efficiency of early imaging, delayed imaging, and their combination for prediction of benign and malignant lesions was compared using receiver operating characteristic (ROC) curves.ResultsFifty-five lesions with abnormal uptake of 99mTc-HYNIC-FAPI-04 were found by SPECT/CT. Compared with TBR-early, TBR-delayed in malignant group was increased (4.07 ± 1.65 vs. 4.36 ± 1.86, P = 0.040), whereas TBR-delayed in the benign group was decreased significantly (2.96 ± 0.85 vs. 2.66 ± 0.77, P < 0.001). The mean count of radioactivity in the delayed phase, TBR-early, TBR-delayed, and RI in the malignant group were higher than those in the benign group (P = 0.005, <0.001, and <0.001, respectively). ROC curves showed that combined application of TBR-early, TBR-delayed, and RI had an AUC of 0.889, specificity of 0.900, and sensitivity of 0.844, and its diagnostic efficiency was superior to that of TBR-delayed (P = 0.026) and TBR-early (P <0.001).ConclusionsDual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT could be used for the detection of metastatic lesions after CRC surgery. It has a higher auxiliary role than single-phase imaging for the differential diagnosis of benign and malignant lesions after CRC surgery. |
| format | Article |
| id | doaj-art-a7bf2e73f9ec4c2b938d41318bbd8da8 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-a7bf2e73f9ec4c2b938d41318bbd8da82025-08-20T03:20:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15002731500273Added value of dual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT in postoperative follow-up of colorectal cancerDonghua Sun0Yan Liu1Renhua Hou2Jianan Li3Ye Peng4Yingqiu Wang5Department of Nuclear Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Nuclear Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Nuclear Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Nuclear Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Nuclear Medicine, the First Affiliated Hospital of Naval Medical University, Shanghai, ChinaDepartment of Nuclear Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, ChinaObjectiveTo assess the added value of dual-phase 99mTc-HYNIC-FAPI-04 single-photon emission computed tomography/computed tomography (SPECT/CT) compared with single-phase imaging in postoperative follow-up of colorectal cancer (CRC).MethodsEarly and delayed 99mTc-HYNIC-FAPI-04 SPECT/CT imaging were undertaken in 21 patients with CRC after surgery. The mean radioactivity count of the lesion site and abdominal aorta in secondary imaging was delineated and measured. The early and delayed target background ratio (TBR) and retention index (RI) were calculated, respectively. The results of biopsy or postoperative pathology, clinical and imaging follow-up were used as the “gold standard” of tumor metastasis. Lesions were divided into “benign” and “malignant” groups. The uptake rate and metabolic rate of 99mTc-HYNIC-FAPI-04 in the two groups were observed. The diagnostic efficiency of early imaging, delayed imaging, and their combination for prediction of benign and malignant lesions was compared using receiver operating characteristic (ROC) curves.ResultsFifty-five lesions with abnormal uptake of 99mTc-HYNIC-FAPI-04 were found by SPECT/CT. Compared with TBR-early, TBR-delayed in malignant group was increased (4.07 ± 1.65 vs. 4.36 ± 1.86, P = 0.040), whereas TBR-delayed in the benign group was decreased significantly (2.96 ± 0.85 vs. 2.66 ± 0.77, P < 0.001). The mean count of radioactivity in the delayed phase, TBR-early, TBR-delayed, and RI in the malignant group were higher than those in the benign group (P = 0.005, <0.001, and <0.001, respectively). ROC curves showed that combined application of TBR-early, TBR-delayed, and RI had an AUC of 0.889, specificity of 0.900, and sensitivity of 0.844, and its diagnostic efficiency was superior to that of TBR-delayed (P = 0.026) and TBR-early (P <0.001).ConclusionsDual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT could be used for the detection of metastatic lesions after CRC surgery. It has a higher auxiliary role than single-phase imaging for the differential diagnosis of benign and malignant lesions after CRC surgery.https://www.frontiersin.org/articles/10.3389/fonc.2025.1500273/full99mTc -HYNIC-FAPI-04SPECT/CTdual-phase imagingcolorectal cancerpostoperative monitoring |
| spellingShingle | Donghua Sun Yan Liu Renhua Hou Jianan Li Ye Peng Yingqiu Wang Added value of dual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT in postoperative follow-up of colorectal cancer Frontiers in Oncology 99mTc -HYNIC-FAPI-04 SPECT/CT dual-phase imaging colorectal cancer postoperative monitoring |
| title | Added value of dual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT in postoperative follow-up of colorectal cancer |
| title_full | Added value of dual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT in postoperative follow-up of colorectal cancer |
| title_fullStr | Added value of dual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT in postoperative follow-up of colorectal cancer |
| title_full_unstemmed | Added value of dual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT in postoperative follow-up of colorectal cancer |
| title_short | Added value of dual-phase 99mTc-HYNIC-FAPI-04 SPECT/CT in postoperative follow-up of colorectal cancer |
| title_sort | added value of dual phase 99mtc hynic fapi 04 spect ct in postoperative follow up of colorectal cancer |
| topic | 99mTc -HYNIC-FAPI-04 SPECT/CT dual-phase imaging colorectal cancer postoperative monitoring |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1500273/full |
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