Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis
This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of CCl4, and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragastric administration for 8 weeks. Liver his...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/93253 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560449063747584 |
|---|---|
| author | Peng Lv Shelley Chireyath Paul Yanjv Xiao Shiquan Liu Hesheng Luo |
| author_facet | Peng Lv Shelley Chireyath Paul Yanjv Xiao Shiquan Liu Hesheng Luo |
| author_sort | Peng Lv |
| collection | DOAJ |
| description | This study was to evaluate the effects of thalidomide on
expression of adhesion molecules in liver cirrhosis. The cirrhosis
was induced in Wistar rats by intraperitoneal injection of
CCl4, and thalidomide (10 mg/kg/day or
100 mg/kg/day) was given by intragastric administration for 8
weeks. Liver histopathology and immunohistochemistry were
significantly improved and the expressions of ICAM-1, VCAM-1,
E-selectin, and TNF-α mRNA and protein were decreased
significantly in rats treated with a high dose of thalidomide.
Close positive correlation was observed in the expression of the
TNF-α mRNA and that of ICAM-1, VCAM-1, and E-selectin mRNA,
respectively. These results indicate that thalidomide exerts its
effect on the downregulation of adhesion molecules via
TNF-α signaling pathway to inhibit liver fibrosis. |
| format | Article |
| id | doaj-art-a7b840b7794f41bf894baae8eba3c261 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a7b840b7794f41bf894baae8eba3c2612025-02-03T01:27:35ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/9325393253Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver CirrhosisPeng Lv0Shelley Chireyath Paul1Yanjv Xiao2Shiquan Liu3Hesheng Luo4Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, ChinaThis study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of CCl4, and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragastric administration for 8 weeks. Liver histopathology and immunohistochemistry were significantly improved and the expressions of ICAM-1, VCAM-1, E-selectin, and TNF-α mRNA and protein were decreased significantly in rats treated with a high dose of thalidomide. Close positive correlation was observed in the expression of the TNF-α mRNA and that of ICAM-1, VCAM-1, and E-selectin mRNA, respectively. These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-α signaling pathway to inhibit liver fibrosis.http://dx.doi.org/10.1155/MI/2006/93253 |
| spellingShingle | Peng Lv Shelley Chireyath Paul Yanjv Xiao Shiquan Liu Hesheng Luo Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis Mediators of Inflammation |
| title | Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis |
| title_full | Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis |
| title_fullStr | Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis |
| title_full_unstemmed | Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis |
| title_short | Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis |
| title_sort | effects of thalidomide on the expression of adhesion molecules in rat liver cirrhosis |
| url | http://dx.doi.org/10.1155/MI/2006/93253 |
| work_keys_str_mv | AT penglv effectsofthalidomideontheexpressionofadhesionmoleculesinratlivercirrhosis AT shelleychireyathpaul effectsofthalidomideontheexpressionofadhesionmoleculesinratlivercirrhosis AT yanjvxiao effectsofthalidomideontheexpressionofadhesionmoleculesinratlivercirrhosis AT shiquanliu effectsofthalidomideontheexpressionofadhesionmoleculesinratlivercirrhosis AT heshengluo effectsofthalidomideontheexpressionofadhesionmoleculesinratlivercirrhosis |