Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis
This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of CCl4, and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragastric administration for 8 weeks. Liver his...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/93253 |
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| Summary: | This study was to evaluate the effects of thalidomide on
expression of adhesion molecules in liver cirrhosis. The cirrhosis
was induced in Wistar rats by intraperitoneal injection of
CCl4, and thalidomide (10 mg/kg/day or
100 mg/kg/day) was given by intragastric administration for 8
weeks. Liver histopathology and immunohistochemistry were
significantly improved and the expressions of ICAM-1, VCAM-1,
E-selectin, and TNF-α mRNA and protein were decreased
significantly in rats treated with a high dose of thalidomide.
Close positive correlation was observed in the expression of the
TNF-α mRNA and that of ICAM-1, VCAM-1, and E-selectin mRNA,
respectively. These results indicate that thalidomide exerts its
effect on the downregulation of adhesion molecules via
TNF-α signaling pathway to inhibit liver fibrosis. |
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| ISSN: | 0962-9351 1466-1861 |