Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review
Background. Myasthenia gravis (MG) is a neuromuscular, autoimmune disease that causes weakness by impairing neuromuscular transmission. According to reports, vaccines can lead to autoimmunity in different ways, and COVID-19 vaccines are suggested to trigger MG. We conducted this systematic review to...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2022/5009450 |
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| author | Omid Mirmosayyeb Elham Moases Ghaffary Mahsa Mazdak Zahra Bagheri Sara Bagherieh Vahid Shaygannejad |
| author_facet | Omid Mirmosayyeb Elham Moases Ghaffary Mahsa Mazdak Zahra Bagheri Sara Bagherieh Vahid Shaygannejad |
| author_sort | Omid Mirmosayyeb |
| collection | DOAJ |
| description | Background. Myasthenia gravis (MG) is a neuromuscular, autoimmune disease that causes weakness by impairing neuromuscular transmission. According to reports, vaccines can lead to autoimmunity in different ways, and COVID-19 vaccines are suggested to trigger MG. We conducted this systematic review to assess MG patients after the COVID-19 vaccination. Methods. We collected 231 studies from four databases from inception to 26 March 2022. Results. 4 case studies were selected from 231 research studies, and data were extracted based on inclusion criteria. In all cases, MG was reported following COVID-19 vaccination. Symptoms such as muscle weakness, numbness, and ptosis were common. The MG was confirmed through RNST, MRC, NCS, and AchR-binding antibody titer tests. Conclusion. Although all cases of MG were diagnosed following appropriate tests, the sample size was small; therefore, further investigation is required to demonstrate the possible association between MG and COVID-19 vaccination. |
| format | Article |
| id | doaj-art-a7b0d5f646594904ac799b941e790138 |
| institution | Kabale University |
| issn | 1918-1493 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-a7b0d5f646594904ac799b941e7901382025-02-03T01:20:06ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1918-14932022-01-01202210.1155/2022/5009450Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic ReviewOmid Mirmosayyeb0Elham Moases Ghaffary1Mahsa Mazdak2Zahra Bagheri3Sara Bagherieh4Vahid Shaygannejad5Department of NeurologyIsfahan Neurosciences Research CenterIsfahan Neurosciences Research CenterIsfahan Neurosciences Research CenterIsfahan Neurosciences Research CenterDepartment of NeurologyBackground. Myasthenia gravis (MG) is a neuromuscular, autoimmune disease that causes weakness by impairing neuromuscular transmission. According to reports, vaccines can lead to autoimmunity in different ways, and COVID-19 vaccines are suggested to trigger MG. We conducted this systematic review to assess MG patients after the COVID-19 vaccination. Methods. We collected 231 studies from four databases from inception to 26 March 2022. Results. 4 case studies were selected from 231 research studies, and data were extracted based on inclusion criteria. In all cases, MG was reported following COVID-19 vaccination. Symptoms such as muscle weakness, numbness, and ptosis were common. The MG was confirmed through RNST, MRC, NCS, and AchR-binding antibody titer tests. Conclusion. Although all cases of MG were diagnosed following appropriate tests, the sample size was small; therefore, further investigation is required to demonstrate the possible association between MG and COVID-19 vaccination.http://dx.doi.org/10.1155/2022/5009450 |
| spellingShingle | Omid Mirmosayyeb Elham Moases Ghaffary Mahsa Mazdak Zahra Bagheri Sara Bagherieh Vahid Shaygannejad Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review |
| title_full | Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review |
| title_fullStr | Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review |
| title_full_unstemmed | Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review |
| title_short | Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review |
| title_sort | is myasthenia gravis a real complication of the covid 19 vaccine a case report based systematic review |
| url | http://dx.doi.org/10.1155/2022/5009450 |
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