Identification of KW-2449 as a dual inhibitor of ferroptosis and necroptosis reveals that autophagy is a targetable pathway for necroptosis inhibitors to prevent ferroptosis

Identification of KW-2449 as a dual inhibitor of ferroptosis and necroptosis reveals that autophagy is a targetable pathway for necroptosis inhibitors to prevent ferroptosis

Abstract Necroptosis and ferroptosis are two distinct forms of necrotic-like cell death in terms of their morphological features and regulatory mechanisms. These two types of cell death can coexist in disease and contribute to pathological processes. Inhibition of both necroptosis and ferroptosis ha...

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Main Authors: Yaxing Zhao, Qingsong Wang, Jing Zhu, Jin Cai, Xiaona Feng, Qianqian Song, Hui Jiang, Wenqing Ren, Yuan He, Ping Wang, Du Feng, Jianqiang Yu, Yue Liu, Qihui Wu, Siriporn Jitkaew, Zhenyu Cai
Format: Article
Language:English
Published: Nature Publishing Group 2024-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07157-9
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