Nonsignaling extracellular spacer regulates tumor antigen selectivity of CAR T cells

Nonsignaling extracellular spacer regulates tumor antigen selectivity of CAR T cells

Advancing chimeric antigen receptor (CAR)-engineered T cells for the treatment of solid tumors is a major focus in the field of cellular immunotherapy. Several hurdles have hindered similar CAR T cell clinical responses in solid tumors as seen in hematological malignancies. These challenges include...

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Bibliographic Details
Main Authors: Kelly T. Kennewick, Yukiko Yamaguchi, Jackson Gibson, Ethan A. Gerdts, Brook Jeang, Dileshni Tilakawardane, John P. Murad, Wen-Chung Chang, Sarah L. Wright, Michalina S. Thiel, Stephen J. Forman, Lawrence A. Stern, Saul J. Priceman
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
chimeric antigen receptor
CAR
prostate cancer
breast cancer
PSCA
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000316
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