MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives
Hepatocellular carcinoma is one of the deadliest and fastest‐growing cancers. Among HCC etiologies, metabolic dysfunction‐associated fatty liver disease (MAFLD) has served as a major HCC driver due to its great potential for increasing cirrhosis. The obesogenic environment fosters a positive energy...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
|
| Series: | Molecular Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/1878-0261.13685 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540618624073728 |
|---|---|
| author | Michael Karin Ju Youn Kim |
| author_facet | Michael Karin Ju Youn Kim |
| author_sort | Michael Karin |
| collection | DOAJ |
| description | Hepatocellular carcinoma is one of the deadliest and fastest‐growing cancers. Among HCC etiologies, metabolic dysfunction‐associated fatty liver disease (MAFLD) has served as a major HCC driver due to its great potential for increasing cirrhosis. The obesogenic environment fosters a positive energy balance and results in a continuous rise of obesity and metabolic syndrome. However, it is difficult to understand how metabolic complications lead to the poor prognosis of liver diseases and which molecular mechanisms are underpinning MAFLD‐driven HCC development. Thus, suitable preclinical models that recapitulate human etiologies are essentially required. Numerous preclinical models have been created but not many mimicked anthropometric measures and the course of disease progression shown in the patients. Here we review the literature on adipose tissues, liver‐related HCC etiologies and recently discovered genetic mutation signatures found in MAFLD‐driven HCC patients. We also critically review current rodent models suggested for MAFLD‐driven HCC study. |
| format | Article |
| id | doaj-art-a78ce82983ac46fe8dccc5432fcbb7cd |
| institution | Kabale University |
| issn | 1574-7891 1878-0261 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj-art-a78ce82983ac46fe8dccc5432fcbb7cd2025-02-04T17:30:20ZengWileyMolecular Oncology1574-78911878-02612025-02-0119227529410.1002/1878-0261.13685MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectivesMichael Karin0Ju Youn Kim1Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine University of California San Diego La Jolla CA USADepartment of Molecular and Life Science Hanyang University ERICA Ansan KoreaHepatocellular carcinoma is one of the deadliest and fastest‐growing cancers. Among HCC etiologies, metabolic dysfunction‐associated fatty liver disease (MAFLD) has served as a major HCC driver due to its great potential for increasing cirrhosis. The obesogenic environment fosters a positive energy balance and results in a continuous rise of obesity and metabolic syndrome. However, it is difficult to understand how metabolic complications lead to the poor prognosis of liver diseases and which molecular mechanisms are underpinning MAFLD‐driven HCC development. Thus, suitable preclinical models that recapitulate human etiologies are essentially required. Numerous preclinical models have been created but not many mimicked anthropometric measures and the course of disease progression shown in the patients. Here we review the literature on adipose tissues, liver‐related HCC etiologies and recently discovered genetic mutation signatures found in MAFLD‐driven HCC patients. We also critically review current rodent models suggested for MAFLD‐driven HCC study.https://doi.org/10.1002/1878-0261.13685ER stressgenetic mutationHepatocellular carcinomainflammationlipotoxicityMASH |
| spellingShingle | Michael Karin Ju Youn Kim MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives Molecular Oncology ER stress genetic mutation Hepatocellular carcinoma inflammation lipotoxicity MASH |
| title | MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives |
| title_full | MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives |
| title_fullStr | MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives |
| title_full_unstemmed | MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives |
| title_short | MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives |
| title_sort | mash as an emerging cause of hepatocellular carcinoma current knowledge and future perspectives |
| topic | ER stress genetic mutation Hepatocellular carcinoma inflammation lipotoxicity MASH |
| url | https://doi.org/10.1002/1878-0261.13685 |
| work_keys_str_mv | AT michaelkarin mashasanemergingcauseofhepatocellularcarcinomacurrentknowledgeandfutureperspectives AT juyounkim mashasanemergingcauseofhepatocellularcarcinomacurrentknowledgeandfutureperspectives |