Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain
Neuropathic pain caused by lesions or nervous system dysfunction is a neuroimmune disease with limited therapeutic options. Adipose tissue-derived stem cells (ASCs) are multipotent mesenchymal stem cells with potent immunosuppressive properties, and their use as novel cell-based therapeutics have be...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8845262 |
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| author | Hyeon Seok Jwa Yong Ho Kim Jaehee Lee Seung-Keun Back Chul-Kyu Park |
| author_facet | Hyeon Seok Jwa Yong Ho Kim Jaehee Lee Seung-Keun Back Chul-Kyu Park |
| author_sort | Hyeon Seok Jwa |
| collection | DOAJ |
| description | Neuropathic pain caused by lesions or nervous system dysfunction is a neuroimmune disease with limited therapeutic options. Adipose tissue-derived stem cells (ASCs) are multipotent mesenchymal stem cells with potent immunosuppressive properties, and their use as novel cell-based therapeutics have been proposed in many immune diseases. However, the analgesic effect and efficacy of ASCs to treat neuropathic pain remain unclear. This study, thus, investigated whether ASCs or ASC-derived culture medium can relieve neuropathic pain behaviors (i.e., mechanical and cold allodynia) in a rat model with L5 spinal nerve ligation. Intrathecal injection of ASCs significantly reduced cold allodynia, but not mechanical allodynia. Importantly, cold allodynia was completely reversed in rats with repeated injections of ASCs. In contrast, intrathecal injection of ASC-derived culture medium or retro-orbital injection of ASCs had no effect on neuropathic pain behaviors. These results suggest a novel and alternative therapeutic application of ASCs to target specific neuropathic pain behaviors. |
| format | Article |
| id | doaj-art-a7785feb18fa456e97bc313e42a8c02d |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-a7785feb18fa456e97bc313e42a8c02d2025-02-03T00:58:52ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88452628845262Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic PainHyeon Seok Jwa0Yong Ho Kim1Jaehee Lee2Seung-Keun Back3Chul-Kyu Park4Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of KoreaDepartment of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of KoreaDepartment of Physiology, College of Medicine, Korea University, Seoul 02841, Republic of KoreaDepartment of Biomedical Laboratory Science, College of Medical Science, Konyang University, Daejeon 158, Republic of KoreaDepartment of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of KoreaNeuropathic pain caused by lesions or nervous system dysfunction is a neuroimmune disease with limited therapeutic options. Adipose tissue-derived stem cells (ASCs) are multipotent mesenchymal stem cells with potent immunosuppressive properties, and their use as novel cell-based therapeutics have been proposed in many immune diseases. However, the analgesic effect and efficacy of ASCs to treat neuropathic pain remain unclear. This study, thus, investigated whether ASCs or ASC-derived culture medium can relieve neuropathic pain behaviors (i.e., mechanical and cold allodynia) in a rat model with L5 spinal nerve ligation. Intrathecal injection of ASCs significantly reduced cold allodynia, but not mechanical allodynia. Importantly, cold allodynia was completely reversed in rats with repeated injections of ASCs. In contrast, intrathecal injection of ASC-derived culture medium or retro-orbital injection of ASCs had no effect on neuropathic pain behaviors. These results suggest a novel and alternative therapeutic application of ASCs to target specific neuropathic pain behaviors.http://dx.doi.org/10.1155/2020/8845262 |
| spellingShingle | Hyeon Seok Jwa Yong Ho Kim Jaehee Lee Seung-Keun Back Chul-Kyu Park Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain Stem Cells International |
| title | Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain |
| title_full | Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain |
| title_fullStr | Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain |
| title_full_unstemmed | Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain |
| title_short | Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain |
| title_sort | adipose tissue derived stem cells alleviate cold allodynia in a rat spinal nerve ligation model of neuropathic pain |
| url | http://dx.doi.org/10.1155/2020/8845262 |
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