Central amygdala neuroimmune signaling in alcohol use disorder
Alcohol Use Disorder (AUD) is a prevalent and debilitating condition characterized by an inability to control alcohol consumption despite adverse consequences. Current treatments for AUD, including FDA-approved medications such as naltrexone and acamprosate, have limited efficacy and compliance, und...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Addiction Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772392524000531 |
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| author | Mariam Melkumyan Patrick A. Randall Yuval Silberman |
| author_facet | Mariam Melkumyan Patrick A. Randall Yuval Silberman |
| author_sort | Mariam Melkumyan |
| collection | DOAJ |
| description | Alcohol Use Disorder (AUD) is a prevalent and debilitating condition characterized by an inability to control alcohol consumption despite adverse consequences. Current treatments for AUD, including FDA-approved medications such as naltrexone and acamprosate, have limited efficacy and compliance, underscoring the need for novel therapeutic approaches. The central amygdala (CeA) plays a crucial role in the development and maintenance of AUD, particularly aspects associated with stress and binge behaviors. Recent research indicates neuroimmune signaling in the CeA is emerging as a key factor in this process. Chronic alcohol consumption disrupts neuroimmune signaling, leading to altered cytokine expression and activation of glial cells, including astrocytes and microglia. These changes contribute to the dysregulation of neural circuits involved in reward and stress, perpetuating alcohol-seeking behavior and relapse. This review delves into how chronic alcohol exposure affects neuroimmune signaling in the CeA, contributing to the pathophysiology of AUD. By focusing on the impact of cytokine expression and glial cell activation, this review aims to elucidate the mechanisms by which neuroinflammation in the CeA influences alcohol-related behaviors. By providing a comprehensive overview of the current state of research, this review identifies potential therapeutic targets for AUD. Understanding the complex interplay between neuroimmune signaling and alcohol-related behaviors may pave the way for more effective treatments and improved outcomes for individuals struggling with AUD. |
| format | Article |
| id | doaj-art-a772c6c9c84e4e4993c3fdfadab06514 |
| institution | Kabale University |
| issn | 2772-3925 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj-art-a772c6c9c84e4e4993c3fdfadab065142025-01-29T05:02:42ZengElsevierAddiction Neuroscience2772-39252025-03-0114100194Central amygdala neuroimmune signaling in alcohol use disorderMariam Melkumyan0Patrick A. Randall1Yuval Silberman2Department of Neural and Behavioral Sciences, Penn State College of Medicine, United StatesDepartment of Anesthesiology, Penn State College of Medicine, United States; Department of Pharmacology, Penn State College of Medicine, United States; Corresponding author at: Department of Anesthesiology and Perioperative Medicine, Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, United States.Department of Neural and Behavioral Sciences, Penn State College of Medicine, United States; Corresponding author at: Department of Neural and Behavioral Sciences, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, United States.Alcohol Use Disorder (AUD) is a prevalent and debilitating condition characterized by an inability to control alcohol consumption despite adverse consequences. Current treatments for AUD, including FDA-approved medications such as naltrexone and acamprosate, have limited efficacy and compliance, underscoring the need for novel therapeutic approaches. The central amygdala (CeA) plays a crucial role in the development and maintenance of AUD, particularly aspects associated with stress and binge behaviors. Recent research indicates neuroimmune signaling in the CeA is emerging as a key factor in this process. Chronic alcohol consumption disrupts neuroimmune signaling, leading to altered cytokine expression and activation of glial cells, including astrocytes and microglia. These changes contribute to the dysregulation of neural circuits involved in reward and stress, perpetuating alcohol-seeking behavior and relapse. This review delves into how chronic alcohol exposure affects neuroimmune signaling in the CeA, contributing to the pathophysiology of AUD. By focusing on the impact of cytokine expression and glial cell activation, this review aims to elucidate the mechanisms by which neuroinflammation in the CeA influences alcohol-related behaviors. By providing a comprehensive overview of the current state of research, this review identifies potential therapeutic targets for AUD. Understanding the complex interplay between neuroimmune signaling and alcohol-related behaviors may pave the way for more effective treatments and improved outcomes for individuals struggling with AUD.http://www.sciencedirect.com/science/article/pii/S2772392524000531Alcohol use disorderNeuroinflammationCentral amygdalaNeuroimmune markers |
| spellingShingle | Mariam Melkumyan Patrick A. Randall Yuval Silberman Central amygdala neuroimmune signaling in alcohol use disorder Addiction Neuroscience Alcohol use disorder Neuroinflammation Central amygdala Neuroimmune markers |
| title | Central amygdala neuroimmune signaling in alcohol use disorder |
| title_full | Central amygdala neuroimmune signaling in alcohol use disorder |
| title_fullStr | Central amygdala neuroimmune signaling in alcohol use disorder |
| title_full_unstemmed | Central amygdala neuroimmune signaling in alcohol use disorder |
| title_short | Central amygdala neuroimmune signaling in alcohol use disorder |
| title_sort | central amygdala neuroimmune signaling in alcohol use disorder |
| topic | Alcohol use disorder Neuroinflammation Central amygdala Neuroimmune markers |
| url | http://www.sciencedirect.com/science/article/pii/S2772392524000531 |
| work_keys_str_mv | AT mariammelkumyan centralamygdalaneuroimmunesignalinginalcoholusedisorder AT patrickarandall centralamygdalaneuroimmunesignalinginalcoholusedisorder AT yuvalsilberman centralamygdalaneuroimmunesignalinginalcoholusedisorder |