Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles
Background. As a transitional state between normal aging and Alzheimer’s disease (AD), mild cognitive impairment (MCI) is characterized by a worse cognitive decline than that of natural aging. The association between AD and gut microbiota has been reported in a number of studies; however, microbial...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/5578958 |
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| author | Qiong Pan Ya-Qian Li Ke Guo Min Xue Yu Gan Kejian Wang Da-Bao Xu Qiu-Yun Tu |
| author_facet | Qiong Pan Ya-Qian Li Ke Guo Min Xue Yu Gan Kejian Wang Da-Bao Xu Qiu-Yun Tu |
| author_sort | Qiong Pan |
| collection | DOAJ |
| description | Background. As a transitional state between normal aging and Alzheimer’s disease (AD), mild cognitive impairment (MCI) is characterized by a worse cognitive decline than that of natural aging. The association between AD and gut microbiota has been reported in a number of studies; however, microbial research regarding MCI remains limited. Methods. This study examined 48 participants, of whom 22 were MCI cases and 26 were normal control cases. Fecal samples were collected for 16S ribosomal RNA (rRNA) quantitative arrays and bioinformatics analysis. Results. A principal coordinates analysis (PCoA) and nonmetric multidimensional scaling (NMDS) both demonstrated that the microbial composition of participants with MCI deviated from that of healthy control participants. Multiple bacterial species were significantly increased (e.g., Staphylococcus intermedius) or decreased (e.g., Bacteroides salyersiae) in samples from the MCI group. Conclusion. The composition of gut microbiota differed between normal control and MCI cases. This is the first study to identify a signature series of species in the gut microbiota of individuals with MCI. The results provide a new direction for the future development of an early diagnosis and probiotic regimen. |
| format | Article |
| id | doaj-art-a76ccd0d99a04678aa138338cf12aaa8 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-a76ccd0d99a04678aa138338cf12aaa82025-02-03T05:59:59ZengWileyJournal of Immunology Research2314-71562021-01-01202110.1155/2021/5578958Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota ProfilesQiong Pan0Ya-Qian Li1Ke Guo2Min Xue3Yu Gan4Kejian Wang5Da-Bao Xu6Qiu-Yun Tu7Department of Obstetrics and GynecologyDepartment of GeriatricsDepartment of NeurologyDepartment of Obstetrics and GynecologyThe Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences)The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences)Department of Obstetrics and GynecologyDepartment of GeriatricsBackground. As a transitional state between normal aging and Alzheimer’s disease (AD), mild cognitive impairment (MCI) is characterized by a worse cognitive decline than that of natural aging. The association between AD and gut microbiota has been reported in a number of studies; however, microbial research regarding MCI remains limited. Methods. This study examined 48 participants, of whom 22 were MCI cases and 26 were normal control cases. Fecal samples were collected for 16S ribosomal RNA (rRNA) quantitative arrays and bioinformatics analysis. Results. A principal coordinates analysis (PCoA) and nonmetric multidimensional scaling (NMDS) both demonstrated that the microbial composition of participants with MCI deviated from that of healthy control participants. Multiple bacterial species were significantly increased (e.g., Staphylococcus intermedius) or decreased (e.g., Bacteroides salyersiae) in samples from the MCI group. Conclusion. The composition of gut microbiota differed between normal control and MCI cases. This is the first study to identify a signature series of species in the gut microbiota of individuals with MCI. The results provide a new direction for the future development of an early diagnosis and probiotic regimen.http://dx.doi.org/10.1155/2021/5578958 |
| spellingShingle | Qiong Pan Ya-Qian Li Ke Guo Min Xue Yu Gan Kejian Wang Da-Bao Xu Qiu-Yun Tu Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles Journal of Immunology Research |
| title | Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles |
| title_full | Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles |
| title_fullStr | Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles |
| title_full_unstemmed | Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles |
| title_short | Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles |
| title_sort | elderly patients with mild cognitive impairment exhibit altered gut microbiota profiles |
| url | http://dx.doi.org/10.1155/2021/5578958 |
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