TSE Diagnostics: Recent Advances in Immunoassaying Prions
Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of rare fatal neurodegenerative diseases, affecting humans and animals. They are believed to be the consequence of the conversion of the cellular prion protein to its aggregation-prone, β-sheet-rich isoform, named prion....
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/360604 |
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| author | Anja Lukan Tanja Vranac Vladka Čurin Šerbec |
| author_facet | Anja Lukan Tanja Vranac Vladka Čurin Šerbec |
| author_sort | Anja Lukan |
| collection | DOAJ |
| description | Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of rare fatal neurodegenerative diseases, affecting humans and animals. They are believed to be the consequence of the conversion of the cellular prion protein to its aggregation-prone, β-sheet-rich isoform, named prion. Definite diagnosis of TSEs is determined post mortem. For this purpose, immunoassays for analyzing brain tissue have been developed. However, the ultimate goal of TSE diagnostics is an ante mortem test, which would be sensitive enough to detect prions in body fluids, that is, in blood, cerebrospinal fluid, or urine. Such a test would be of paramount importance also for screening of asymptomatic carriers of the disease with the aim of increasing food, drugs, and blood-derived products safety. In the present paper, we have reviewed recent advances in the development of immunoassays for the detection of prions. |
| format | Article |
| id | doaj-art-a765c626f9f145ecab7cd1055e25d4b7 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-a765c626f9f145ecab7cd1055e25d4b72025-02-03T01:25:55ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/360604360604TSE Diagnostics: Recent Advances in Immunoassaying PrionsAnja Lukan0Tanja Vranac1Vladka Čurin Šerbec2Department for Production of Diagnostic Reagents and Research, Blood Transfusion Centre of Slovenia, Šlajmerjeva 6, 1000 Ljubljana, SloveniaDepartment for Production of Diagnostic Reagents and Research, Blood Transfusion Centre of Slovenia, Šlajmerjeva 6, 1000 Ljubljana, SloveniaDepartment for Production of Diagnostic Reagents and Research, Blood Transfusion Centre of Slovenia, Šlajmerjeva 6, 1000 Ljubljana, SloveniaTransmissible spongiform encephalopathies (TSEs) or prion diseases are a group of rare fatal neurodegenerative diseases, affecting humans and animals. They are believed to be the consequence of the conversion of the cellular prion protein to its aggregation-prone, β-sheet-rich isoform, named prion. Definite diagnosis of TSEs is determined post mortem. For this purpose, immunoassays for analyzing brain tissue have been developed. However, the ultimate goal of TSE diagnostics is an ante mortem test, which would be sensitive enough to detect prions in body fluids, that is, in blood, cerebrospinal fluid, or urine. Such a test would be of paramount importance also for screening of asymptomatic carriers of the disease with the aim of increasing food, drugs, and blood-derived products safety. In the present paper, we have reviewed recent advances in the development of immunoassays for the detection of prions.http://dx.doi.org/10.1155/2013/360604 |
| spellingShingle | Anja Lukan Tanja Vranac Vladka Čurin Šerbec TSE Diagnostics: Recent Advances in Immunoassaying Prions Clinical and Developmental Immunology |
| title | TSE Diagnostics: Recent Advances in Immunoassaying Prions |
| title_full | TSE Diagnostics: Recent Advances in Immunoassaying Prions |
| title_fullStr | TSE Diagnostics: Recent Advances in Immunoassaying Prions |
| title_full_unstemmed | TSE Diagnostics: Recent Advances in Immunoassaying Prions |
| title_short | TSE Diagnostics: Recent Advances in Immunoassaying Prions |
| title_sort | tse diagnostics recent advances in immunoassaying prions |
| url | http://dx.doi.org/10.1155/2013/360604 |
| work_keys_str_mv | AT anjalukan tsediagnosticsrecentadvancesinimmunoassayingprions AT tanjavranac tsediagnosticsrecentadvancesinimmunoassayingprions AT vladkacurinserbec tsediagnosticsrecentadvancesinimmunoassayingprions |