Enabling malic acid production from corn-stover hydrolysate in Lipomyces starkeyi via metabolic engineering and bioprocess optimization

Enabling malic acid production from corn-stover hydrolysate in Lipomyces starkeyi via metabolic engineering and bioprocess optimization

Abstract Background Lipomyces starkeyi is an oleaginous yeast with a native metabolism well-suited for production of lipids and biofuels from complex lignocellulosic and waste feedstocks. Recent advances in genetic engineering tools have facilitated the development of L. starkeyi into a microbial ch...

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Main Authors: Jeffrey J. Czajka, Ziyu Dai, Tijana Radivojević, Joonhoon Kim, Shuang Deng, Teresa Lemmon, Marie Swita, Meagan C Burnet, Nathalie Munoz, Yuqian Gao, Young-Mo Kim, Beth Hofstad, Jon K. Magnuson, Hector Garcia Martin, Kristin E. Burnum-Johnson, Kyle R. Pomraning
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Microbial Cell Factories
Subjects:
Oleaginous yeast
Lipomyces starkeyi
Malic acid production
Machine learning medium optimization
Online Access:https://doi.org/10.1186/s12934-025-02705-0
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