Cloning Approaches for Identifying Aging and Longevity-Related Genes in Mammals
Aging is a phenomenon that affects nearly all animal species. Several studies using different systems have identified a number of processes thought to contribute to the aging phenotype. Many differentially expressed genes have been implicated, but the mechanisms governing mammalian aging (and longev...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.117 |
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| author | Davina C. Simoes Efstathios S. Gonos |
| author_facet | Davina C. Simoes Efstathios S. Gonos |
| author_sort | Davina C. Simoes |
| collection | DOAJ |
| description | Aging is a phenomenon that affects nearly all animal species. Several studies using different systems have identified a number of processes thought to contribute to the aging phenotype. Many differentially expressed genes have been implicated, but the mechanisms governing mammalian aging (and longevity) are not yet fully understood, and the list of concerned genes is still incomplete and fragmented. Different approaches have been used to clone aging and longevity-related genes. In this article we review these cloning techniques and discuss their advantages and limitations. Further research on the function of these genes as well as the network of their protein products will give better insight into the aging process as a whole and its associated pathologies. |
| format | Article |
| id | doaj-art-a753002e319b487d9ec0bd0d54c9ec80 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a753002e319b487d9ec0bd0d54c9ec802025-02-03T05:49:35ZengWileyThe Scientific World Journal1537-744X2002-01-01248349110.1100/tsw.2002.117Cloning Approaches for Identifying Aging and Longevity-Related Genes in MammalsDavina C. Simoes0Efstathios S. Gonos1National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vas. Constantinou Ave., Athens 11635, GreeceNational Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vas. Constantinou Ave., Athens 11635, GreeceAging is a phenomenon that affects nearly all animal species. Several studies using different systems have identified a number of processes thought to contribute to the aging phenotype. Many differentially expressed genes have been implicated, but the mechanisms governing mammalian aging (and longevity) are not yet fully understood, and the list of concerned genes is still incomplete and fragmented. Different approaches have been used to clone aging and longevity-related genes. In this article we review these cloning techniques and discuss their advantages and limitations. Further research on the function of these genes as well as the network of their protein products will give better insight into the aging process as a whole and its associated pathologies.http://dx.doi.org/10.1100/tsw.2002.117 |
| spellingShingle | Davina C. Simoes Efstathios S. Gonos Cloning Approaches for Identifying Aging and Longevity-Related Genes in Mammals The Scientific World Journal |
| title | Cloning Approaches for Identifying Aging and Longevity-Related Genes in Mammals |
| title_full | Cloning Approaches for Identifying Aging and Longevity-Related Genes in Mammals |
| title_fullStr | Cloning Approaches for Identifying Aging and Longevity-Related Genes in Mammals |
| title_full_unstemmed | Cloning Approaches for Identifying Aging and Longevity-Related Genes in Mammals |
| title_short | Cloning Approaches for Identifying Aging and Longevity-Related Genes in Mammals |
| title_sort | cloning approaches for identifying aging and longevity related genes in mammals |
| url | http://dx.doi.org/10.1100/tsw.2002.117 |
| work_keys_str_mv | AT davinacsimoes cloningapproachesforidentifyingagingandlongevityrelatedgenesinmammals AT efstathiossgonos cloningapproachesforidentifyingagingandlongevityrelatedgenesinmammals |