Chemical composition, antioxidant, antimicrobial and antiviral activities of the leaf extracts of Syzygium myrtifolium
This study was conducted to evaluate the chemical composition and biological activities of the leaf extracts of Syzygium myrtifolium Walp. (Myrtaceae). The results indicate that the leaf extracts of S. myrtifolium contain various classes of phytochemicals (alkaloids, anthraquinones, flavonoids, phen...
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| Format: | Article |
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2022-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2022-0013 |
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| author | AHMAD MUSTAFFA ALBAKRI LIM YI HUI CHAN YIK SIN HSU CHUN-YUAN WU TZONG-YUAN SIT NAM WENG |
| author_facet | AHMAD MUSTAFFA ALBAKRI LIM YI HUI CHAN YIK SIN HSU CHUN-YUAN WU TZONG-YUAN SIT NAM WENG |
| author_sort | AHMAD MUSTAFFA ALBAKRI |
| collection | DOAJ |
| description | This study was conducted to evaluate the chemical composition and biological activities of the leaf extracts of Syzygium myrtifolium Walp. (Myrtaceae). The results indicate that the leaf extracts of S. myrtifolium contain various classes of phytochemicals (alkaloids, anthraquinones, flavonoids, phenolics, saponins, tannins and triterpenoids) and possess antioxidant, antibacterial, antifungal and antiviral activities. Ethyl acetate, ethanol, methanol, and water extracts exhibited significantly higher (p < 0.05) oxygen radical absorbance capacity and ferric-reducing antioxidant power than the hexane and chloroform extracts. However, all extracts exhibited stronger inhibitory activity against four tested species of yeasts (minimal inhibitory concentration: 0.02–0.31 mg mL–1) than against six tested species of bacteria (minimal inhibitory concentration: 0.16–1.25 mg mL–1). The ethanolic extract offered the highest protection of Vero cells (viability > 70 %) from the cytopathic effect caused by the Chikungunya virus while the ethyl acetate extract showed significant replication inhibitory activity against the virus (p < 0.001) using the replicon-enhanced green fluorescent protein reporter system. |
| format | Article |
| id | doaj-art-a734ae647d754b3582c50e60074ed869 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-a734ae647d754b3582c50e60074ed8692025-02-02T02:10:55ZengSciendoActa Pharmaceutica1846-95582022-06-0172231732810.2478/acph-2022-0013Chemical composition, antioxidant, antimicrobial and antiviral activities of the leaf extracts of Syzygium myrtifoliumAHMAD MUSTAFFA ALBAKRI0LIM YI HUI1CHAN YIK SIN2HSU CHUN-YUAN3WU TZONG-YUAN4SIT NAM WENG51Department of Allied Health Sciences Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900Kampar, Perak, Malaysia1Department of Allied Health Sciences Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900Kampar, Perak, Malaysia1Department of Allied Health Sciences Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900Kampar, Perak, Malaysia2Department of Bioscience Technology College of Science, Chung Yuan Christian University, Chung Li District, Taiwan32023, R.O.C.2Department of Bioscience Technology College of Science, Chung Yuan Christian University, Chung Li District, Taiwan32023, R.O.C.1Department of Allied Health Sciences Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900Kampar, Perak, MalaysiaThis study was conducted to evaluate the chemical composition and biological activities of the leaf extracts of Syzygium myrtifolium Walp. (Myrtaceae). The results indicate that the leaf extracts of S. myrtifolium contain various classes of phytochemicals (alkaloids, anthraquinones, flavonoids, phenolics, saponins, tannins and triterpenoids) and possess antioxidant, antibacterial, antifungal and antiviral activities. Ethyl acetate, ethanol, methanol, and water extracts exhibited significantly higher (p < 0.05) oxygen radical absorbance capacity and ferric-reducing antioxidant power than the hexane and chloroform extracts. However, all extracts exhibited stronger inhibitory activity against four tested species of yeasts (minimal inhibitory concentration: 0.02–0.31 mg mL–1) than against six tested species of bacteria (minimal inhibitory concentration: 0.16–1.25 mg mL–1). The ethanolic extract offered the highest protection of Vero cells (viability > 70 %) from the cytopathic effect caused by the Chikungunya virus while the ethyl acetate extract showed significant replication inhibitory activity against the virus (p < 0.001) using the replicon-enhanced green fluorescent protein reporter system.https://doi.org/10.2478/acph-2022-0013syzygium myrtifolium leafantibacterialantifungalantioxidantchikungunya virusrecombinant baculovirus |
| spellingShingle | AHMAD MUSTAFFA ALBAKRI LIM YI HUI CHAN YIK SIN HSU CHUN-YUAN WU TZONG-YUAN SIT NAM WENG Chemical composition, antioxidant, antimicrobial and antiviral activities of the leaf extracts of Syzygium myrtifolium Acta Pharmaceutica syzygium myrtifolium leaf antibacterial antifungal antioxidant chikungunya virus recombinant baculovirus |
| title | Chemical composition, antioxidant, antimicrobial and antiviral activities of the leaf extracts of Syzygium myrtifolium |
| title_full | Chemical composition, antioxidant, antimicrobial and antiviral activities of the leaf extracts of Syzygium myrtifolium |
| title_fullStr | Chemical composition, antioxidant, antimicrobial and antiviral activities of the leaf extracts of Syzygium myrtifolium |
| title_full_unstemmed | Chemical composition, antioxidant, antimicrobial and antiviral activities of the leaf extracts of Syzygium myrtifolium |
| title_short | Chemical composition, antioxidant, antimicrobial and antiviral activities of the leaf extracts of Syzygium myrtifolium |
| title_sort | chemical composition antioxidant antimicrobial and antiviral activities of the leaf extracts of syzygium myrtifolium |
| topic | syzygium myrtifolium leaf antibacterial antifungal antioxidant chikungunya virus recombinant baculovirus |
| url | https://doi.org/10.2478/acph-2022-0013 |
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