Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage

Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage

Abstract Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung disease characterized by chronic airway inflammation and emphysema. Macrophage polarization plays an important role in COPD pathogenesis by secreting inflammatory mediators. Bromodomain-containing protein...

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Main Authors: Difei Li, Xing Shi, Yuqiong Yang, Yao Deng, Dandan Chen, Shuyu Chen, Jinyong Wang, Guanxi Wen, Zhenyu Liang, Fengyan Wang, Jiaqi Gao, Yuanyuan Liu, Danna Wang, Ruifang Liang, Haizhao Xu, Rongchang Chen, Shanze Chen, Lingwei Wang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Respiratory Research
Subjects:
Chronic obstructive pulmonary disease (COPD)
Bromodomain-containing protein 4 (BRD4)
Alveolar macrophage polarization
Super-enhancers
ARV-825
Online Access:https://doi.org/10.1186/s12931-025-03120-0
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