Impaired intestinal calcium absorption and osteopathy in ICR/Mlac-hydro mice with hypoparathyroidism and severe hydronephrosis

Impaired intestinal calcium absorption and osteopathy in ICR/Mlac-hydro mice with hypoparathyroidism and severe hydronephrosis

Abstract Abnormal fluid accumulation in the renal pelvis and calyces, with enlargement of the pelvicalyceal system, leads to a devastating disease known as hydronephrosis, which subsequently induces progressive renal impairment and mineral imbalance. Since the renal tubular cells play a role in the...

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Bibliographic Details
Main Authors: Panan Suntornsaratoon, Kannikar Wongdee, Nithipak Thammayon, Jarinthorn Teerapornpuntakit, Nattapon Panupinthu, Wacharaporn Tiyasatkulkovit, Sarawut Lapmanee, Krittikan Chanpaisaeng, Surachai Chantip, Narattaphol Charoenphandhu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Bone loss
Calcium absorption
Hydronephrosis
Micro-computed tomography (µCT)
Vitamin D
Online Access:https://doi.org/10.1038/s41598-025-06485-w
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