Global Dynamics of a Delayed HIV-1 Infection Model with CTL Immune Response

A delayed HIV-1 infection model with CTL immune response is investigated. By using suitable Lyapunov functionals, it is proved that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio for viral infection is less than or equal to unity; if the basic reprod...

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Bibliographic Details
Main Authors: Yunfei Li, Rui Xu, Zhe Li, Shuxue Mao
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Discrete Dynamics in Nature and Society
Online Access:http://dx.doi.org/10.1155/2011/673843
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Summary:A delayed HIV-1 infection model with CTL immune response is investigated. By using suitable Lyapunov functionals, it is proved that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio for viral infection is less than or equal to unity; if the basic reproduction ratio for CTL immune response is less than or equal to unity and the basic reproduction ratio for viral infection is greater than unity, the CTL-inactivated infection equilibrium is globally asymptotically stable; if the basic reproduction ratio for CTL immune response is greater than unity, the CTL-activated infection equilibrium is globally asymptotically stable.
ISSN:1026-0226
1607-887X