Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort

Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort

Abstract Background Second-generation tau tracers for positron emission tomography (PET) show high affinity for paired helical filaments tau deposits characteristic of Alzheimer´s disease and low off-target binding. Differences in their chemical structure though may lead to variations in their regio...

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Main Authors: Matteo Tonietto, Oscar Sotolongo-Grau, Núria Roé-Vellvé, Santiago Bullich, Juan Pablo Tartari, Ángela Sanabria, Ainhoa García-Sánchez, Edilio Borroni, Christopher Galli, Esther Pérez-Martínez, Joan Castell-Conesa, Isabel Roca, Lluís Tárraga, Agustín Ruiz, Andrew W. Stephens, Mercè Boada, Gregory Klein, Marta Marquié, on behalf of the FACEHBI study group, on behalf of the AMYPAD consortium
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Tau
Positron emission tomography
[18F]PI-2620
[18F]RO948
FACEHBI
Subjective cognitive decline
Online Access:https://doi.org/10.1186/s13195-024-01622-5
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