Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care Use
Point-of-care (POC) use is one of the essential goals of biosensing platforms. Because the increasing demand for testing cannot be met by a centralized laboratory-based strategy, rapid and frequent testing at the right time and place will be key to increasing health and safety. To date, however, the...
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MDPI AG
2025-01-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/1/13 |
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| author | Sang-Uk Kim Young Jun Kim Tae Hee Lee |
| author_facet | Sang-Uk Kim Young Jun Kim Tae Hee Lee |
| author_sort | Sang-Uk Kim |
| collection | DOAJ |
| description | Point-of-care (POC) use is one of the essential goals of biosensing platforms. Because the increasing demand for testing cannot be met by a centralized laboratory-based strategy, rapid and frequent testing at the right time and place will be key to increasing health and safety. To date, however, there are still difficulties in developing a simple and affordable, as well as sensitive and effective, platform that enables POC use. In terms of materials, hydrogels, a unique family of water-absorbing biocompatible polymers, have emerged as promising components for the development of biosensors. Combinations of hydrogels have various additional applications, such as in hydrophilic coatings, nanoscale filtration, stimuli-responsive materials, signal enhancement, and biodegradation. In this review, we highlight the recent efforts to develop hydrogel-assisted biosensing platforms for POC use, especially focusing on polysaccharide hydrogels like agarose, alginate, chitosan, and so on. We first discuss the pros and cons of polysaccharide hydrogels in practical applications and then introduce case studies that test different formats, such as paper-based analytical devices (PADs), microfluidic devices, and independent platforms. We believe the analysis in the present review provides essential information for the development of biosensing platforms for POC use in resource-limited settings. |
| format | Article |
| id | doaj-art-a6fbfa3da3f947498c175bec298d2d2f |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-a6fbfa3da3f947498c175bec298d2d2f2025-01-24T13:25:26ZengMDPI AGBiosensors2079-63742025-01-011511310.3390/bios15010013Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care UseSang-Uk Kim0Young Jun Kim1Tae Hee Lee2Korea Science and Technology Holdings, Ltd., 593, Daedoek-Daero, Yuseong-Gu, Daejeon 34112, Republic of KoreaSchool of Integrative Engineering, Chung-Ang University, 4, Heukseok-Ro, Dongjak-Gu, Seoul 06974, Republic of KoreaDepartment of Biomedical Laboratory Science, Daegu Health College, Chang-ui Building, 15 Yeongsong-ro, Buk-gu, Daegu 41453, Republic of KoreaPoint-of-care (POC) use is one of the essential goals of biosensing platforms. Because the increasing demand for testing cannot be met by a centralized laboratory-based strategy, rapid and frequent testing at the right time and place will be key to increasing health and safety. To date, however, there are still difficulties in developing a simple and affordable, as well as sensitive and effective, platform that enables POC use. In terms of materials, hydrogels, a unique family of water-absorbing biocompatible polymers, have emerged as promising components for the development of biosensors. Combinations of hydrogels have various additional applications, such as in hydrophilic coatings, nanoscale filtration, stimuli-responsive materials, signal enhancement, and biodegradation. In this review, we highlight the recent efforts to develop hydrogel-assisted biosensing platforms for POC use, especially focusing on polysaccharide hydrogels like agarose, alginate, chitosan, and so on. We first discuss the pros and cons of polysaccharide hydrogels in practical applications and then introduce case studies that test different formats, such as paper-based analytical devices (PADs), microfluidic devices, and independent platforms. We believe the analysis in the present review provides essential information for the development of biosensing platforms for POC use in resource-limited settings.https://www.mdpi.com/2079-6374/15/1/13polysaccharidehydrogelpoint-of-care testingbiosensorpaper-based analytical devicemicrofluidics |
| spellingShingle | Sang-Uk Kim Young Jun Kim Tae Hee Lee Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care Use Biosensors polysaccharide hydrogel point-of-care testing biosensor paper-based analytical device microfluidics |
| title | Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care Use |
| title_full | Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care Use |
| title_fullStr | Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care Use |
| title_full_unstemmed | Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care Use |
| title_short | Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care Use |
| title_sort | polysaccharide hydrogel assisted biosensing platforms for point of care use |
| topic | polysaccharide hydrogel point-of-care testing biosensor paper-based analytical device microfluidics |
| url | https://www.mdpi.com/2079-6374/15/1/13 |
| work_keys_str_mv | AT sangukkim polysaccharidehydrogelassistedbiosensingplatformsforpointofcareuse AT youngjunkim polysaccharidehydrogelassistedbiosensingplatformsforpointofcareuse AT taeheelee polysaccharidehydrogelassistedbiosensingplatformsforpointofcareuse |