Preexisting Cardiovascular Risk Factors and Coronary Artery Atherosclerosis in Patients with and without Cancer
Cancer survivors suffer a higher risk of coronary artery atherosclerosis (CAA). Whether cancer patients had increased baseline CAA burden prior to cardiotoxic therapy remains unclear. We conducted a case-control study, and 286 consecutive patients were finally included. Among these patients, 181 had...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/4570926 |
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| author | Junyi Guo Peng Fang Wei Shi Pengcheng Luo Shengqi Huo Dan Yan Moran Wang Dewei Peng Lintong Men Sheng Li Jiagao Lv Li Lin |
| author_facet | Junyi Guo Peng Fang Wei Shi Pengcheng Luo Shengqi Huo Dan Yan Moran Wang Dewei Peng Lintong Men Sheng Li Jiagao Lv Li Lin |
| author_sort | Junyi Guo |
| collection | DOAJ |
| description | Cancer survivors suffer a higher risk of coronary artery atherosclerosis (CAA). Whether cancer patients had increased baseline CAA burden prior to cardiotoxic therapy remains unclear. We conducted a case-control study, and 286 consecutive patients were finally included. Among these patients, 181 had newly diagnosed cancer and 105 had nonmalignant diseases. Cancer was confirmed by biopsy. The severity of CAA was determined by coronary angiography and evaluated using the percentage of stenosis or Gensini scoring (GS). Patients with cancer versus cancer-free controls were older (OR = 1.052, 95% CI: 1.021–1.084, p<0.001), more commonly male (OR = 0.048, 95% CI: 1.004–2.676, p=0.048), and more severely exposed to smoking (OR = 1.020, 95% CI: 1.007–1.033, p=0.003). Cancer patients were significantly more commonly complicated by ≥90% coronary stenosis than the gender- and age-matched cancer-free controls (9/93 versus 1/93, OR = 4.875, 95% CI: 1.024–23.213, p=0.047). After adjustment for age, gender, hypertension, diabetes, smoking history, blood glucose, and total cholesterol, cancer was significantly associated with high GS (adjusted OR = 2.208, 95% CI: 1.077–4.524, p=0.031). Our study demonstrated that cancer patients had increased CAA burden prior to cardiotoxic therapy. Further study is necessary to investigate the link between CAA and cancer. |
| format | Article |
| id | doaj-art-a6f5c3e25eca4d1bacbf49520d55866a |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-a6f5c3e25eca4d1bacbf49520d55866a2025-02-03T06:14:11ZengWileyCardiology Research and Practice2090-05972022-01-01202210.1155/2022/4570926Preexisting Cardiovascular Risk Factors and Coronary Artery Atherosclerosis in Patients with and without CancerJunyi Guo0Peng Fang1Wei Shi2Pengcheng Luo3Shengqi Huo4Dan Yan5Moran Wang6Dewei Peng7Lintong Men8Sheng Li9Jiagao Lv10Li Lin11Division of CardiologyDivision of CardiologyDivision of CardiologyDepartment of GeriatricsDivision of CardiologyDepartment of GeriatricsDivision of CardiologyDivision of CardiologyDivision of CardiologyDivision of CardiologyDivision of CardiologyDivision of CardiologyCancer survivors suffer a higher risk of coronary artery atherosclerosis (CAA). Whether cancer patients had increased baseline CAA burden prior to cardiotoxic therapy remains unclear. We conducted a case-control study, and 286 consecutive patients were finally included. Among these patients, 181 had newly diagnosed cancer and 105 had nonmalignant diseases. Cancer was confirmed by biopsy. The severity of CAA was determined by coronary angiography and evaluated using the percentage of stenosis or Gensini scoring (GS). Patients with cancer versus cancer-free controls were older (OR = 1.052, 95% CI: 1.021–1.084, p<0.001), more commonly male (OR = 0.048, 95% CI: 1.004–2.676, p=0.048), and more severely exposed to smoking (OR = 1.020, 95% CI: 1.007–1.033, p=0.003). Cancer patients were significantly more commonly complicated by ≥90% coronary stenosis than the gender- and age-matched cancer-free controls (9/93 versus 1/93, OR = 4.875, 95% CI: 1.024–23.213, p=0.047). After adjustment for age, gender, hypertension, diabetes, smoking history, blood glucose, and total cholesterol, cancer was significantly associated with high GS (adjusted OR = 2.208, 95% CI: 1.077–4.524, p=0.031). Our study demonstrated that cancer patients had increased CAA burden prior to cardiotoxic therapy. Further study is necessary to investigate the link between CAA and cancer.http://dx.doi.org/10.1155/2022/4570926 |
| spellingShingle | Junyi Guo Peng Fang Wei Shi Pengcheng Luo Shengqi Huo Dan Yan Moran Wang Dewei Peng Lintong Men Sheng Li Jiagao Lv Li Lin Preexisting Cardiovascular Risk Factors and Coronary Artery Atherosclerosis in Patients with and without Cancer Cardiology Research and Practice |
| title | Preexisting Cardiovascular Risk Factors and Coronary Artery Atherosclerosis in Patients with and without Cancer |
| title_full | Preexisting Cardiovascular Risk Factors and Coronary Artery Atherosclerosis in Patients with and without Cancer |
| title_fullStr | Preexisting Cardiovascular Risk Factors and Coronary Artery Atherosclerosis in Patients with and without Cancer |
| title_full_unstemmed | Preexisting Cardiovascular Risk Factors and Coronary Artery Atherosclerosis in Patients with and without Cancer |
| title_short | Preexisting Cardiovascular Risk Factors and Coronary Artery Atherosclerosis in Patients with and without Cancer |
| title_sort | preexisting cardiovascular risk factors and coronary artery atherosclerosis in patients with and without cancer |
| url | http://dx.doi.org/10.1155/2022/4570926 |
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