Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate

Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate

In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model. Therefore anti-inflammatory effect of MI-1 on rat acetic acid induced ulcerative col...

Full description

Saved in:

Bibliographic Details
Main Authors:	Halyna M. Kuznietsova, Maryna S. Yena, Iryna P. Kotlyar, Olexandr V. Ogloblya, Volodymyr K. Rybalchenko
Format:	Article
Language:	English
Published:	Wiley 2016-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1155/2016/2145753
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

3D-QSAR Study on a Series of VEGFR-2 Kinase Inhibitors: 3-Pyrrole Substituted Indolin-2-Ones Compounds
by: Shunlai Li, et al.
Published: (2013-01-01)

Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation
by: Jungwoon Lee, et al.
Published: (2019-01-01)

Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders
by: Muhammad Waleed Iqbal, et al.
Published: (2025-01-01)

Enhanced Optical and Thermal Stability of Blue Pyrrole Derivatives for Color Filter in Image Sensors
by: Sunwoo Park, et al.
Published: (2025-01-01)

Unveiling the Anti-Angiogenic Potential of Small-Molecule (Kinase) Inhibitors for Application in Rheumatoid Arthritis
by: Fatemeh Khodadust, et al.
Published: (2025-01-01)

Proteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors
by: Dimitris Korovesis, et al.
Published: (2025-02-01)

Janus kinase inhibitor treatment for inflammatory diseases: excess or no excess risk of venous thromboembolism?
by: Yachar Dawudi, et al.
Published: (2025-01-01)

Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics.
by: Md Nayab Sulaimani, et al.
Published: (2025-01-01)

Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro
by: Hyun Sang Cho, et al.
Published: (2025-01-01)

The structure–activity relationship and computational studies of 1,3-thiazole derivatives as cholinesterase inhibitors with anti-inflammatory activity
by: Modrić, Marina, et al.
Published: (2022-09-01)

Protein kinase inhibitors as targeted therapy for glioblastoma: a meta-analysis of randomized controlled clinical trials
by: José Pinto-Fraga, et al.
Published: (2025-02-01)

Receptor Tyrosine Kinases and Inhibitors in Lung Cancer
by: Evan Pisick, et al.
Published: (2004-01-01)

An Anaplastic Lymphoma Kinase-positive Inflammatory Myofibroblastic Tumor with Rapidly Acquired Resistance to First-line Anaplastic Lymphoma Kinase Inhibitor: A Case and Literature Review
by: Shu-Cheng Wu, et al.
Published: (2024-01-01)

Charge transfer control by substituents: Donor pyrroles and fluoro-anilines
by: Antje Neubauer, et al.
Published: (2005-01-01)

Synthesis, in vitro safety and antioxidant activity of new pyrrole hydrazones
by: Tzankova Diana, et al.
Published: (2020-09-01)

Cardiovascular safety of Janus kinase inhibitors in inflammatory bowel disease: a systematic review and network meta-analysis
by: Huibin Yang, et al.
Published: (2025-12-01)

Protein tyrosine kinase but not protein kinase C inhibition blocks receptor induced alveolar macrophage activation
by: K. Pollock, et al.
Published: (1993-01-01)

Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives
by: Chenchen Shi, et al.
Published: (2015-01-01)

Selective Immunomodulation of Inflammatory Pathways in Keratinocytes by the Janus Kinase (JAK) Inhibitor Tofacitinib: Implications for the Employment of JAK-Targeting Drugs in Psoriasis
by: Martina Morelli, et al.
Published: (2018-01-01)

Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C
by: Wan-Jung Lu, et al.
Published: (2014-01-01)

Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs
by: Yoonhee Kim, et al.
Published: (2025-01-01)

Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N
by: Julius Bogomolovas, et al.
Published: (2025-01-01)

Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction
by: Lijiang Wei, et al.
Published: (2025-01-01)

Targeting Cutaneous Leishmaniasis with Thiadiazine Thione Derivatives: An In Vivo Study of Its Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, and Anti-Sedative Properties
by: Sarah Sarwar, et al.
Published: (2025-01-01)

Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities
by: Chunyun Xu, et al.
Published: (2025-01-01)

Synthesis of Furo[3,2-b]pyrrole-5-carboxhydrazides and Their Cu, CO and Ni Complexes
by: Renata Gašparová, et al.
Published: (2012-01-01)

Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment
by: Anna Carbone, et al.
Published: (2025-02-01)

Effects of the Rho-Kinase Inhibitor Y-27632 on Extraocular Muscle Surgery in Rabbits
by: Ji‐Sun Moon, et al.
Published: (2017-01-01)

Janus kinase inhibitors and biologics for treatment of livedoid vasculopathy: a systematic review
by: Yu Liu, et al.
Published: (2025-12-01)

Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors
by: Yousef Sabah Ali, et al.
Published: (2025-01-01)

Anti-Inflammatory Effects of IKK Inhibitor XII, Thymulin, and Fat-Soluble Antioxidants in LPS-Treated Mice
by: E. G. Novoselova, et al.
Published: (2014-01-01)

BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets
by: Jaehwi Lee, et al.
Published: (2012-01-01)

Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents
by: Muhammad Abdullah Bhatti, et al.
Published: (2025-02-01)

Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease
by: William Z. Suo, et al.
Published: (2010-01-01)

Complete Assignment of H1 and C13 NMR Spectra of 1,2,4-Trisubstituted Pyrroles
by: Elsa Anselmi, et al.
Published: (2013-01-01)

Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties
by: Sibusiso Rali, et al.
Published: (2016-01-01)

Therapeutic Applicability of Anti-Inflammatory and Proresolving Polyunsaturated Fatty Acid-Derived Lipid Mediators
by: Gerard L. Bannenberg
Published: (2010-01-01)

Non-Steroidal Anti-Inflammatory Drugs Are Inhibitors of the Intestinal Proton-Coupled Amino Acid Transporter (PAT1): Ibuprofen and Diclofenac Are Non-Translocated Inhibitors
by: Carsten Uhd Nielsen, et al.
Published: (2025-01-01)

Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor
by: Salvador Gallardo-Alfonzo, et al.
Published: (2014-01-01)

FDA-approved kinase inhibitors: a promising therapeutic avenue for traumatic brain injury
by: Dezhu Gao, et al.
Published: (2024-12-01)