Chorioamnionitis and Lung Injury in Preterm Newborns
There is a strong evidence that histologic chorioamnionitis is associated with a reduction of incidence and severity of respiratory distress syndrome (RDS). Short-term maturational effects on the lungs of extremely premature infants seem to be, however, accompanied by a greater susceptibility of the...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/890987 |
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| author | Gustavo Rocha |
| author_facet | Gustavo Rocha |
| author_sort | Gustavo Rocha |
| collection | DOAJ |
| description | There is a strong evidence that histologic chorioamnionitis is associated with a reduction of incidence and severity of respiratory distress syndrome (RDS). Short-term maturational effects on the lungs of extremely premature infants seem to be, however, accompanied by a greater susceptibility of the lung, eventually contributing to an increased risk of bronchopulmonary dysplasia (BPD). Genetic susceptibility to BPD is an evolving area of research and several studies have directly related the risk of BPD to genomic variants. There is a substantial heterogeneity across the studies in the magnitude of the association between chorioamnionitis and BPD, and whether or not the association is statistically significant. Considerable variation is largely dependent on differences of inclusion and exclusion criteria, as well as on clinical and histopathological definitions. The presence of significant publication bias may exaggerate the magnitude of the association. Controlling for publication bias may conduct to adjusted results that are no longer significant. Recent studies generally seem to confirm the effect of chorioamnionitis on RDS incidence, while no effect on BPD is seen. Recent data suggest susceptibility for subsequent asthma to be increased on long-term followup. Additional research on this field is needed. |
| format | Article |
| id | doaj-art-a6da4a3bce3a499ebcd533f85f0b5ba4 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-a6da4a3bce3a499ebcd533f85f0b5ba42025-02-03T01:09:03ZengWileyCritical Care Research and Practice2090-13052090-13132013-01-01201310.1155/2013/890987890987Chorioamnionitis and Lung Injury in Preterm NewbornsGustavo Rocha0Division of Neonatology, Department of Pediatrics, São João Hospital, 4202-451 Porto, PortugalThere is a strong evidence that histologic chorioamnionitis is associated with a reduction of incidence and severity of respiratory distress syndrome (RDS). Short-term maturational effects on the lungs of extremely premature infants seem to be, however, accompanied by a greater susceptibility of the lung, eventually contributing to an increased risk of bronchopulmonary dysplasia (BPD). Genetic susceptibility to BPD is an evolving area of research and several studies have directly related the risk of BPD to genomic variants. There is a substantial heterogeneity across the studies in the magnitude of the association between chorioamnionitis and BPD, and whether or not the association is statistically significant. Considerable variation is largely dependent on differences of inclusion and exclusion criteria, as well as on clinical and histopathological definitions. The presence of significant publication bias may exaggerate the magnitude of the association. Controlling for publication bias may conduct to adjusted results that are no longer significant. Recent studies generally seem to confirm the effect of chorioamnionitis on RDS incidence, while no effect on BPD is seen. Recent data suggest susceptibility for subsequent asthma to be increased on long-term followup. Additional research on this field is needed.http://dx.doi.org/10.1155/2013/890987 |
| spellingShingle | Gustavo Rocha Chorioamnionitis and Lung Injury in Preterm Newborns Critical Care Research and Practice |
| title | Chorioamnionitis and Lung Injury in Preterm Newborns |
| title_full | Chorioamnionitis and Lung Injury in Preterm Newborns |
| title_fullStr | Chorioamnionitis and Lung Injury in Preterm Newborns |
| title_full_unstemmed | Chorioamnionitis and Lung Injury in Preterm Newborns |
| title_short | Chorioamnionitis and Lung Injury in Preterm Newborns |
| title_sort | chorioamnionitis and lung injury in preterm newborns |
| url | http://dx.doi.org/10.1155/2013/890987 |
| work_keys_str_mv | AT gustavorocha chorioamnionitisandlunginjuryinpretermnewborns |