Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs

Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs

BackgroundCelastrol, an active ingredient derived from Tripterygium wilfordii Hook F, has shown therapeutic potential for various kidney renal diseases. The kidney protective activity of celastrol is mainly exerted through anti-inflammatory, and antioxidant effects. However, celastrol causes dose-de...

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Bibliographic Details
Main Authors:	Chongayng Shen, Qizheng Wang, Xun Ye, Yi Zhou, Huayang Xing, Chengjie Pan, Heying Li, Chunjie Wu, Mingliang You
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Pharmacology
Subjects:	celastrol kidney organoids nephrotoxicity cisplatin SNORD3A
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1464525/full
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