Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional study
ObjectiveKidney stones are a major issue for public health worldwide. Discovering potential clues in identifying at-risk individuals is essential for early detection and timely treatment. This study explores the relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) with...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1523890/full |
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| author | Yuan-Zhuo Du Jia-Qing Yang Ji-Ming Yao Chi-Teng Zhang Yi-Fu Liu |
| author_facet | Yuan-Zhuo Du Jia-Qing Yang Ji-Ming Yao Chi-Teng Zhang Yi-Fu Liu |
| author_sort | Yuan-Zhuo Du |
| collection | DOAJ |
| description | ObjectiveKidney stones are a major issue for public health worldwide. Discovering potential clues in identifying at-risk individuals is essential for early detection and timely treatment. This study explores the relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) with the risk of kidney stones in U.S. adults.MethodsThe analysis involved 24,532 participants with available NHR and kidney stone data from the 2007–2018 NHANES period. Multivariable logistic regression models were used to quantify the relationship between NHR and kidney stone occurrence. Subgroup analyses were conducted to explore variations in effect.ResultsA total of 2,351 participants (9.93%) were diagnosed with kidney stones, and their mean age was 47.20 ± 0.26 years. After full adjustment in the multivariable regression model, higher NHR levels were linked to a greater risk of kidney stones (OR = 1.05, 95% CI: 1.02–1.08, P = 0.002). Participants in the highest tertile of NHR had a 34% increased chance of kidney stone development compared to those in the lowest tertile. A nonlinear connection between NHR and kidney stone risk was identified using restricted cubic spline (RCS) regression models. The relationship between NHR and kidney stone prevalence showed no significant variation across most subgroups (P for interaction > 0.05).ConclusionThe results indicate that increased NHR is linked to a higher risk of kidney stones, with this relationship remaining consistent across various populations. NHR could be a useful biomarker for kidney stone risk, with key implications for early detection and individualized treatment. |
| format | Article |
| id | doaj-art-a6cc17a0b514471a9936339c908cd78f |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-a6cc17a0b514471a9936339c908cd78f2025-02-03T05:12:00ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15238901523890Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional studyYuan-Zhuo Du0Jia-Qing Yang1Ji-Ming Yao2Chi-Teng Zhang3Yi-Fu Liu4Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe Second Affiliated Hospital, Department of Urology, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe Second Affiliated Hospital, Department of Urology, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaObjectiveKidney stones are a major issue for public health worldwide. Discovering potential clues in identifying at-risk individuals is essential for early detection and timely treatment. This study explores the relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) with the risk of kidney stones in U.S. adults.MethodsThe analysis involved 24,532 participants with available NHR and kidney stone data from the 2007–2018 NHANES period. Multivariable logistic regression models were used to quantify the relationship between NHR and kidney stone occurrence. Subgroup analyses were conducted to explore variations in effect.ResultsA total of 2,351 participants (9.93%) were diagnosed with kidney stones, and their mean age was 47.20 ± 0.26 years. After full adjustment in the multivariable regression model, higher NHR levels were linked to a greater risk of kidney stones (OR = 1.05, 95% CI: 1.02–1.08, P = 0.002). Participants in the highest tertile of NHR had a 34% increased chance of kidney stone development compared to those in the lowest tertile. A nonlinear connection between NHR and kidney stone risk was identified using restricted cubic spline (RCS) regression models. The relationship between NHR and kidney stone prevalence showed no significant variation across most subgroups (P for interaction > 0.05).ConclusionThe results indicate that increased NHR is linked to a higher risk of kidney stones, with this relationship remaining consistent across various populations. NHR could be a useful biomarker for kidney stone risk, with key implications for early detection and individualized treatment.https://www.frontiersin.org/articles/10.3389/fendo.2025.1523890/fullneutrophil-to-high-density lipoprotein cholesterol ratiokidney stonesneutrophilhigh-density lipoprotein cholesterolcross-sectional study |
| spellingShingle | Yuan-Zhuo Du Jia-Qing Yang Ji-Ming Yao Chi-Teng Zhang Yi-Fu Liu Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional study Frontiers in Endocrinology neutrophil-to-high-density lipoprotein cholesterol ratio kidney stones neutrophil high-density lipoprotein cholesterol cross-sectional study |
| title | Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional study |
| title_full | Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional study |
| title_fullStr | Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional study |
| title_full_unstemmed | Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional study |
| title_short | Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional study |
| title_sort | association between the neutrophil to high density lipoprotein cholesterol ratio with kidney stone risk a cross sectional study |
| topic | neutrophil-to-high-density lipoprotein cholesterol ratio kidney stones neutrophil high-density lipoprotein cholesterol cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1523890/full |
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