The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections
There is increasing interest in understanding the mechanisms underlying the interactions that occur between Mycobacterium tuberculosis and host innate immune cells. These cells express pattern recognition receptors (PRRs) which recognise mycobacterial pathogen-associated molecular patterns (PAMPs) a...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/567571 |
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| author | Mohlopheni Jackson Marakalala Lisa M. Graham Gordon D. Brown |
| author_facet | Mohlopheni Jackson Marakalala Lisa M. Graham Gordon D. Brown |
| author_sort | Mohlopheni Jackson Marakalala |
| collection | DOAJ |
| description | There is increasing interest in understanding the mechanisms underlying the interactions that occur between Mycobacterium tuberculosis and host innate immune cells. These cells express pattern recognition receptors (PRRs) which recognise mycobacterial pathogen-associated molecular patterns (PAMPs) and which can influence the host immune response to the infection. Although many of the PRRs appear to be redundant in the control of M. tuberculosis infection in vivo, recent discoveries have revealed a key, nonredundant, role of the Syk/CARD9 signalling pathway in antimycobacterial immunity. Here we review these discoveries, as well as recent data investigating the role of the Syk/CARD9-coupled PRRs that have been implicated in mycobacterial recognition, including Dectin-1 and Mincle. |
| format | Article |
| id | doaj-art-a6bd297aed8941e3b6e2e827c8137434 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-a6bd297aed8941e3b6e2e827c81374342025-02-03T05:57:11ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/567571567571The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis InfectionsMohlopheni Jackson Marakalala0Lisa M. Graham1Gordon D. Brown2Institute of Infectious Diseases and Molecular Medicine, Division of Immunology, CLS, University of Cape Town, Cape Town 7925, South AfricaInstitute of Infectious Diseases and Molecular Medicine, Division of Immunology, CLS, University of Cape Town, Cape Town 7925, South AfricaAberdeen Fungal Group, Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UKThere is increasing interest in understanding the mechanisms underlying the interactions that occur between Mycobacterium tuberculosis and host innate immune cells. These cells express pattern recognition receptors (PRRs) which recognise mycobacterial pathogen-associated molecular patterns (PAMPs) and which can influence the host immune response to the infection. Although many of the PRRs appear to be redundant in the control of M. tuberculosis infection in vivo, recent discoveries have revealed a key, nonredundant, role of the Syk/CARD9 signalling pathway in antimycobacterial immunity. Here we review these discoveries, as well as recent data investigating the role of the Syk/CARD9-coupled PRRs that have been implicated in mycobacterial recognition, including Dectin-1 and Mincle.http://dx.doi.org/10.1155/2010/567571 |
| spellingShingle | Mohlopheni Jackson Marakalala Lisa M. Graham Gordon D. Brown The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections Clinical and Developmental Immunology |
| title | The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections |
| title_full | The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections |
| title_fullStr | The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections |
| title_full_unstemmed | The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections |
| title_short | The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections |
| title_sort | role of syk card9 coupled c type lectin receptors in immunity to mycobacterium tuberculosis infections |
| url | http://dx.doi.org/10.1155/2010/567571 |
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