CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer

CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer

Abstract Poly (ADP‐ribose) Polymerase inhibitors (PARPi) have demonstrated remarkable clinical efficacy in treating ovarian cancer (OV) with BRCA1/2 mutations. However, drug resistance inevitably limits their clinical applications and there is an urgent need for improved therapeutic strategies to en...

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Main Authors: Shini Liu, Peng Deng, Zhaoliang Yu, Jing Han Hong, Jiuping Gao, Yulin Huang, Rong Xiao, Jiaxin Yin, Xian Zeng, Yichen Sun, Peili Wang, Ruizi Geng, Jason Yongsheng Chan, Peiyong Guan, Qiang Yu, Bin‐Tean Teh, Qingping Jiang, Xiaojun Xia, Ying Xiong, Jianfeng Chen, Yongliang Huo, Jing Tan
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
CDC7 inhibitor
immune activation
ovarian cancer
PARP inhibitor resistance
target therapy
Online Access:https://doi.org/10.1002/advs.202403782
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