Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4

Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4

ABSTRACT Previous studies have shown that E6 interacts with the E6-associated protein (E6AP) ubiquitin-protein ligase and directs its ubiquitylation activity toward several specific cellular proteins, one of the most important of which is p53. Interestingly, E6AP not only aids in the E6-directed deg...

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Bibliographic Details
Main Authors: Arushi Vats, Luca Braga, Nezka Kavcic, Paola Massimi, Edoardo Schneider, Mauro Giacca, Laimonis A. Laimins, Lawrence Banks
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
Subjects:
HPV
E6
E6AP
FBXO4
Online Access:https://journals.asm.org/doi/10.1128/mbio.02783-24
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