Trajectory of changes in myelin basic protein levels in cerebrospinal fluid during ageing and its association with biomarkers of Alzheimer’s disease
Abstract Myelin loss has been implicated in the development of Alzheimer’s disease (AD). We investigated the changes in myelin basic protein (MBP) levels in cerebrospinal fluid (CSF) in an ageing cohort comprising 116 cognitively normal and Aβ-negative controls aged 26 to 82 years, as well as in a c...
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| Main Authors: | Man-Yu Xu, Xu Yi, Shan Huang, Qing-Hua Wang, Yu-Jie Lai, Zhen Wang, Dong-Yu Fan, Gui-Hua Zeng, Yu-Di Bai, Ying-Ying Shen, Fan Zeng, Qing-Xiang Mao, Zhi-Qiang Xu, Feng Mei, Yan-Jiang Wang, Jun Wang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-04-01
|
| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-025-03369-5 |
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