The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context
Summary: Background: Although the number of studies reporting war-induced effects on the health of the Ukrainian population has been growing, there are still little data on assessing patients with type 2 diabetes (T2D) during the war. This study aimed to evaluate the impact of war on T2D patients’...
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Elsevier
2025-01-01
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| Series: | EClinicalMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258953702400587X |
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| author | Oksana Sulaieva Viktoriia Yerokhovych Sergii Zemskov Iuliia Komisarenko Vitalii Gurianov Volodymyr Pankiv Oleksandr Tovkai Tetyana Yuzvenko Violetta Yuzvenko Andrii Tovkai Zlatoslava Shaienko Tetyana Falalyeyeva Nadiya Skrypnyk Taras Romaniv Nadiya Pasyechko Taras Krytskyy Solomiia Danyliuk Andrii Klantsa Dmytro Krasnienkov Oleksandr Gurbych Nazarii Kobyliak |
| author_facet | Oksana Sulaieva Viktoriia Yerokhovych Sergii Zemskov Iuliia Komisarenko Vitalii Gurianov Volodymyr Pankiv Oleksandr Tovkai Tetyana Yuzvenko Violetta Yuzvenko Andrii Tovkai Zlatoslava Shaienko Tetyana Falalyeyeva Nadiya Skrypnyk Taras Romaniv Nadiya Pasyechko Taras Krytskyy Solomiia Danyliuk Andrii Klantsa Dmytro Krasnienkov Oleksandr Gurbych Nazarii Kobyliak |
| author_sort | Oksana Sulaieva |
| collection | DOAJ |
| description | Summary: Background: Although the number of studies reporting war-induced effects on the health of the Ukrainian population has been growing, there are still little data on assessing patients with type 2 diabetes (T2D) during the war. This study aimed to evaluate the impact of war on T2D patients’ health to define key risk factors promoting disease progression. Methods: A survey covering various aspects of T2D patients’ experience and glycemic control data was conducted from June 2022 to February 2024. Overall, 1193 patients from all regions of Ukraine were enrolled in the study. According to the difference between the initial and current levels of HbA1c, all the respondents were subdivided into two categories: progressors (with HbA1c levels greater than 5% of the initial value) and stable (patients with stable HbA1c levels). Next, the impact of intrinsic and war-related factors on T2D progression was assessed via logistic regression analysis and machine learning tools. Findings: Two years of war experience was associated with significant increase in the median HbA1c from 7.8% (7.0–8.93) to 8.4% (7.4–9.9; p < 0.001), with the highest value occurring in eastern and northern Ukraine. HbA1c levels demonstrated a time-dependent pattern of growth, reflecting the cumulative effect of war-related factors on T2D patients’ health. Witnesses of armed attacks and occupation aggravated the T2D course. Experience with military actions (p = 0.002), occupation (p = 0.001), internal displacement (p = 0.018) and family member injury or death (p = 0.031) increased HbA1c. In addition, lack of regular glucose monitoring (p < 0.001), consultation by endocrinologists (p < 0.001), diet inconsistency (p = 0.017) and scarcity of physical activity (p = 0.047) affected the HbA1c parameters. Interpretation: This study demonstrated a dramatic cumulative effect of the war on T2D patients’ health. Uncovered direct and indirect war-related risk factors can guide further adjustment of diabetic care in Ukraine to improve T2D patient support. Funding: National Research Foundation of Ukraine (grant number 2022.01/0089). |
| format | Article |
| id | doaj-art-a69a6b1787b448b38be88e9f11d36d6b |
| institution | Kabale University |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj-art-a69a6b1787b448b38be88e9f11d36d6b2025-01-22T05:43:39ZengElsevierEClinicalMedicine2589-53702025-01-0179103008The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in contextOksana Sulaieva0Viktoriia Yerokhovych1Sergii Zemskov2Iuliia Komisarenko3Vitalii Gurianov4Volodymyr Pankiv5Oleksandr Tovkai6Tetyana Yuzvenko7Violetta Yuzvenko8Andrii Tovkai9Zlatoslava Shaienko10Tetyana Falalyeyeva11Nadiya Skrypnyk12Taras Romaniv13Nadiya Pasyechko14Taras Krytskyy15Solomiia Danyliuk16Andrii Klantsa17Dmytro Krasnienkov18Oleksandr Gurbych19Nazarii Kobyliak20Medical Laboratory CSD, Kyiv 02000, Ukraine; Kyiv Medical University, Kyiv 02099, UkraineBogomolets National Medical University, Kyiv 01024, UkraineBogomolets National Medical University, Kyiv 01024, UkraineBogomolets National Medical University, Kyiv 01024, UkraineBogomolets National Medical University, Kyiv 01024, UkraineUkrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv 01021, UkraineUkrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv 01021, UkraineUkrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv 01021, UkraineBogomolets National Medical University, Kyiv 01024, Ukraine; Ukrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv 01021, UkraineBogomolets National Medical University, Kyiv 01024, UkrainePoltava State Medical University, Poltava 36011, UkraineMedical Laboratory CSD, Kyiv 02000, Ukraine; Educational-Scientific Center “Institute of Biology and Medicine” Taras Shevchenko National University of Kyiv, Kyiv 01601, UkraineIvano-Frankivsk National Medical University, Ivano-Frankivsk 76000, UkraineIvano-Frankivsk National Medical University, Ivano-Frankivsk 76000, UkraineI. Horbachevsky Ternopil National Medical University, Ternopil 46001, UkraineI. Horbachevsky Ternopil National Medical University, Ternopil 46001, UkraineCommunal Nonprofit Enterprise of Khmelnitsky Local Self-Government “Khmelnitsky Regional Cardiovascular Center”, Khmelnitsky 29001, UkraineCommunal Nonprofit Enterprise of Khmelnitsky Local Self-Government “Khmelnitsky Regional Cardiovascular Center”, Khmelnitsky 29001, UkraineD.F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine; Blackthorn AI, Ltd., London, UKBlackthorn AI, Ltd., London, UK; Lviv Polytechnic National University, Lviv 79000, UkraineMedical Laboratory CSD, Kyiv 02000, Ukraine; Bogomolets National Medical University, Kyiv 01024, Ukraine; Corresponding author. Bogomolets National Medical University, Endocrinology Department, Ievgena Chykalenka 22a str., Kyiv 01024, Ukraine.Summary: Background: Although the number of studies reporting war-induced effects on the health of the Ukrainian population has been growing, there are still little data on assessing patients with type 2 diabetes (T2D) during the war. This study aimed to evaluate the impact of war on T2D patients’ health to define key risk factors promoting disease progression. Methods: A survey covering various aspects of T2D patients’ experience and glycemic control data was conducted from June 2022 to February 2024. Overall, 1193 patients from all regions of Ukraine were enrolled in the study. According to the difference between the initial and current levels of HbA1c, all the respondents were subdivided into two categories: progressors (with HbA1c levels greater than 5% of the initial value) and stable (patients with stable HbA1c levels). Next, the impact of intrinsic and war-related factors on T2D progression was assessed via logistic regression analysis and machine learning tools. Findings: Two years of war experience was associated with significant increase in the median HbA1c from 7.8% (7.0–8.93) to 8.4% (7.4–9.9; p < 0.001), with the highest value occurring in eastern and northern Ukraine. HbA1c levels demonstrated a time-dependent pattern of growth, reflecting the cumulative effect of war-related factors on T2D patients’ health. Witnesses of armed attacks and occupation aggravated the T2D course. Experience with military actions (p = 0.002), occupation (p = 0.001), internal displacement (p = 0.018) and family member injury or death (p = 0.031) increased HbA1c. In addition, lack of regular glucose monitoring (p < 0.001), consultation by endocrinologists (p < 0.001), diet inconsistency (p = 0.017) and scarcity of physical activity (p = 0.047) affected the HbA1c parameters. Interpretation: This study demonstrated a dramatic cumulative effect of the war on T2D patients’ health. Uncovered direct and indirect war-related risk factors can guide further adjustment of diabetic care in Ukraine to improve T2D patient support. Funding: National Research Foundation of Ukraine (grant number 2022.01/0089).http://www.sciencedirect.com/science/article/pii/S258953702400587XType 2 diabetesWarHumanitarian crisisDisplacementDisasterChronic stress |
| spellingShingle | Oksana Sulaieva Viktoriia Yerokhovych Sergii Zemskov Iuliia Komisarenko Vitalii Gurianov Volodymyr Pankiv Oleksandr Tovkai Tetyana Yuzvenko Violetta Yuzvenko Andrii Tovkai Zlatoslava Shaienko Tetyana Falalyeyeva Nadiya Skrypnyk Taras Romaniv Nadiya Pasyechko Taras Krytskyy Solomiia Danyliuk Andrii Klantsa Dmytro Krasnienkov Oleksandr Gurbych Nazarii Kobyliak The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context EClinicalMedicine Type 2 diabetes War Humanitarian crisis Displacement Disaster Chronic stress |
| title | The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context |
| title_full | The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context |
| title_fullStr | The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context |
| title_full_unstemmed | The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context |
| title_short | The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context |
| title_sort | impact of war on people with type 2 diabetes in ukraine a survey studyresearch in context |
| topic | Type 2 diabetes War Humanitarian crisis Displacement Disaster Chronic stress |
| url | http://www.sciencedirect.com/science/article/pii/S258953702400587X |
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