Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s Disease
Both Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) share a common neuropathological marker, the presence of Lewy bodies in brain stem and basal forebrain nuclei. DLB, in addition, is associated with Lewy bodies in the neocortex, and, in it’s more common form, with Alzheimer-type patho...
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/1999/851860 |
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| author | John Joseph Downes Nicholas M. Priestley Mark Doran Jose Ferran Eric Ghadiali Paul Cooper |
| author_facet | John Joseph Downes Nicholas M. Priestley Mark Doran Jose Ferran Eric Ghadiali Paul Cooper |
| author_sort | John Joseph Downes |
| collection | DOAJ |
| description | Both Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) share a common neuropathological marker, the presence of Lewy bodies in brain stem and basal forebrain nuclei. DLB, in addition, is associated with Lewy bodies in the neocortex, and, in it’s more common form, with Alzheimer-type pathological markers, particularly amyloid plaques. Published neuropsychological studies have focused on the differential profiles of DLB and Alzheimer’s disease (AD). However, it is presently unclear whether DLB should be classified as a variant of AD or PD. In the present study we compare a healthy age-matched control group with three groups of patients, one with DLB, and two with PD. One of the PD groups was early in the course (PD-E) and the second, more advanced group (PD-A), was matched on severity of cognitive impairment with the DLB group. The results show that DLB was associated with a different pattern of neuropsychological impairment than the PD-A group, particularly in tests believed to be mediated by prefrontal cortical regions. |
| format | Article |
| id | doaj-art-a6914db7c48f48c19c90b43b975d23f3 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-a6914db7c48f48c19c90b43b975d23f32025-08-20T03:38:39ZengWileyBehavioural Neurology0953-41801875-85841999-01-0111317318310.1155/1999/851860Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s DiseaseJohn Joseph Downes0Nicholas M. Priestley1Mark Doran2Jose Ferran3Eric Ghadiali4Paul Cooper5Department of Psychology, University of Liverpool, UKThe Walton Centre for Neurology and Neurosurgery, Liverpool, UKThe Walton Centre for Neurology and Neurosurgery, Liverpool, UKThe Walton Centre for Neurology and Neurosurgery, Liverpool, UKThe Walton Centre for Neurology and Neurosurgery, Liverpool, UKThe Walton Centre for Neurology and Neurosurgery, Liverpool, UKBoth Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) share a common neuropathological marker, the presence of Lewy bodies in brain stem and basal forebrain nuclei. DLB, in addition, is associated with Lewy bodies in the neocortex, and, in it’s more common form, with Alzheimer-type pathological markers, particularly amyloid plaques. Published neuropsychological studies have focused on the differential profiles of DLB and Alzheimer’s disease (AD). However, it is presently unclear whether DLB should be classified as a variant of AD or PD. In the present study we compare a healthy age-matched control group with three groups of patients, one with DLB, and two with PD. One of the PD groups was early in the course (PD-E) and the second, more advanced group (PD-A), was matched on severity of cognitive impairment with the DLB group. The results show that DLB was associated with a different pattern of neuropsychological impairment than the PD-A group, particularly in tests believed to be mediated by prefrontal cortical regions.http://dx.doi.org/10.1155/1999/851860 |
| spellingShingle | John Joseph Downes Nicholas M. Priestley Mark Doran Jose Ferran Eric Ghadiali Paul Cooper Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s Disease Behavioural Neurology |
| title | Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s Disease |
| title_full | Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s Disease |
| title_fullStr | Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s Disease |
| title_full_unstemmed | Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s Disease |
| title_short | Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s Disease |
| title_sort | intellectual mnemonic and frontal functions in dementia with lewy bodies a comparison with early and advanced parkinson s disease |
| url | http://dx.doi.org/10.1155/1999/851860 |
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