The Rieske Iron-Sulfur Protein: Import and Assembly into the Cytochrome 𝑏𝑐1 Complex of Yeast Mitochondria
The Rieske iron-sulfur protein, one of the catalytic subunits of the cytochrome 𝑏𝑐1 complex, is involved in electron transfer at the level of the inner membrane of yeast mitochondria. The Rieske iron-sulfur protein is encoded by nuclear DNA and, after being synthesized in the cytosol, is imported in...
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| Format: | Article |
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Wiley
2011-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2011/363941 |
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| author | Laura Conte Vincenzo Zara |
| author_facet | Laura Conte Vincenzo Zara |
| author_sort | Laura Conte |
| collection | DOAJ |
| description | The Rieske iron-sulfur protein, one of the catalytic subunits of the cytochrome 𝑏𝑐1 complex, is involved in electron transfer at the level of the inner membrane of yeast mitochondria. The Rieske iron-sulfur protein is encoded by nuclear DNA and, after being synthesized in the cytosol, is imported into mitochondria with the help of a cleavable N-terminal presequence. The imported protein, besides incorporating the 2Fe-2S cluster, also interacts with other catalytic and non-catalytic subunits of the cytochrome 𝑏𝑐1 complex, thereby assembling into the mature and functional respiratory complex. In this paper, we summarize the most recent findings on the import and assembly of the Rieske iron-sulfur protein into Saccharomyces cerevisiae mitochondria, also discussing a possible role of this protein both in the dimerization of the cytochrome 𝑏𝑐1 complex and in the interaction of this homodimer with other complexes of the mitochondrial respiratory chain. |
| format | Article |
| id | doaj-art-a68feacc6909446787bac0f09cb77e54 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-a68feacc6909446787bac0f09cb77e542025-02-03T01:21:24ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2011-01-01201110.1155/2011/363941363941The Rieske Iron-Sulfur Protein: Import and Assembly into the Cytochrome 𝑏𝑐1 Complex of Yeast MitochondriaLaura Conte0Vincenzo Zara1Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Prov.le Lecce-Monteroni, 73100 Lecce, ItalyDipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Prov.le Lecce-Monteroni, 73100 Lecce, ItalyThe Rieske iron-sulfur protein, one of the catalytic subunits of the cytochrome 𝑏𝑐1 complex, is involved in electron transfer at the level of the inner membrane of yeast mitochondria. The Rieske iron-sulfur protein is encoded by nuclear DNA and, after being synthesized in the cytosol, is imported into mitochondria with the help of a cleavable N-terminal presequence. The imported protein, besides incorporating the 2Fe-2S cluster, also interacts with other catalytic and non-catalytic subunits of the cytochrome 𝑏𝑐1 complex, thereby assembling into the mature and functional respiratory complex. In this paper, we summarize the most recent findings on the import and assembly of the Rieske iron-sulfur protein into Saccharomyces cerevisiae mitochondria, also discussing a possible role of this protein both in the dimerization of the cytochrome 𝑏𝑐1 complex and in the interaction of this homodimer with other complexes of the mitochondrial respiratory chain.http://dx.doi.org/10.1155/2011/363941 |
| spellingShingle | Laura Conte Vincenzo Zara The Rieske Iron-Sulfur Protein: Import and Assembly into the Cytochrome 𝑏𝑐1 Complex of Yeast Mitochondria Bioinorganic Chemistry and Applications |
| title | The Rieske Iron-Sulfur Protein: Import and Assembly into the Cytochrome 𝑏𝑐1 Complex of Yeast Mitochondria |
| title_full | The Rieske Iron-Sulfur Protein: Import and Assembly into the Cytochrome 𝑏𝑐1 Complex of Yeast Mitochondria |
| title_fullStr | The Rieske Iron-Sulfur Protein: Import and Assembly into the Cytochrome 𝑏𝑐1 Complex of Yeast Mitochondria |
| title_full_unstemmed | The Rieske Iron-Sulfur Protein: Import and Assembly into the Cytochrome 𝑏𝑐1 Complex of Yeast Mitochondria |
| title_short | The Rieske Iron-Sulfur Protein: Import and Assembly into the Cytochrome 𝑏𝑐1 Complex of Yeast Mitochondria |
| title_sort | rieske iron sulfur protein import and assembly into the cytochrome 𝑏𝑐1 complex of yeast mitochondria |
| url | http://dx.doi.org/10.1155/2011/363941 |
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