Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus
Objective. Seizure disorders are one of the most disabling, life-threatening, and the least understood syndromes associated with neuropsychiatric SLE (NPSLE). N-Methyl-D-aspartate (NMDA) receptors are a subgroup of the glutamate receptor family, whose NR2A subunit was found on neuronal cells (anti-N...
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| Format: | Article |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/5047898 |
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| author | Yan Yang Chao Yuan Shu-qun Shen Xue-er Wang Qing-hua Mei Wen-qing Jiang Qin Huang |
| author_facet | Yan Yang Chao Yuan Shu-qun Shen Xue-er Wang Qing-hua Mei Wen-qing Jiang Qin Huang |
| author_sort | Yan Yang |
| collection | DOAJ |
| description | Objective. Seizure disorders are one of the most disabling, life-threatening, and the least understood syndromes associated with neuropsychiatric SLE (NPSLE). N-Methyl-D-aspartate (NMDA) receptors are a subgroup of the glutamate receptor family, whose NR2A subunit was found on neuronal cells (anti-NR2A) in NPSLE patients with different types of epilepsy. The present study was conducted to determine the serum levels of anti-NR2A antibodies in a large group of SLE patients, to investigate the possible correlation between the presence of the NR2A specific antibodies and NPSLE-related seizure disorders. Methods and Results. The study population consisted of 107 SLE patients and 43 age- and sex-matched healthy controls. 73 SLE patients had active disease. 36 of these had NPSLE. NMDA levels were measured by ELISA. Clinical and serological parameters were assessed according to routine procedures. The levels of anti-NR2A antibodies were significantly higher in NPSLE patients, compared with non-NPSLE patients and healthy controls. Furthermore, the levels of NPSLE in patients with seizure disorders were shown to be higher than in those with cognitive dysfunction and other CNS symptoms, however, without significance. Increase in serum anti-NR2A antibodies levels correlated to anti-dsDNA antibody and SLEDAI as well as complement levels. Conclusion. We suggest that anti-NR2A antibodies play a role in the pathogenesis of NPSLE with seizure disorders. |
| format | Article |
| id | doaj-art-a68924b91bfe4a6a8127b9b595afa027 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
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| series | Mediators of Inflammation |
| spelling | doaj-art-a68924b91bfe4a6a8127b9b595afa0272025-02-03T06:05:05ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/50478985047898Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus ErythematosusYan Yang0Chao Yuan1Shu-qun Shen2Xue-er Wang3Qing-hua Mei4Wen-qing Jiang5Qin Huang6Guangdong No. 2 Provincial People’s Hospital, Courtyard No. 466, Middle Xingang Road, Haizhu District, Guangzhou 510317, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaSchool of Public Health, Southern Medical University, No. 1023 South Shatai Rd., Guangzhou, Guangdong 510515, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, ChinaGuangdong No. 2 Provincial People’s Hospital, Courtyard No. 466, Middle Xingang Road, Haizhu District, Guangzhou 510317, ChinaNanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Rheumatology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaObjective. Seizure disorders are one of the most disabling, life-threatening, and the least understood syndromes associated with neuropsychiatric SLE (NPSLE). N-Methyl-D-aspartate (NMDA) receptors are a subgroup of the glutamate receptor family, whose NR2A subunit was found on neuronal cells (anti-NR2A) in NPSLE patients with different types of epilepsy. The present study was conducted to determine the serum levels of anti-NR2A antibodies in a large group of SLE patients, to investigate the possible correlation between the presence of the NR2A specific antibodies and NPSLE-related seizure disorders. Methods and Results. The study population consisted of 107 SLE patients and 43 age- and sex-matched healthy controls. 73 SLE patients had active disease. 36 of these had NPSLE. NMDA levels were measured by ELISA. Clinical and serological parameters were assessed according to routine procedures. The levels of anti-NR2A antibodies were significantly higher in NPSLE patients, compared with non-NPSLE patients and healthy controls. Furthermore, the levels of NPSLE in patients with seizure disorders were shown to be higher than in those with cognitive dysfunction and other CNS symptoms, however, without significance. Increase in serum anti-NR2A antibodies levels correlated to anti-dsDNA antibody and SLEDAI as well as complement levels. Conclusion. We suggest that anti-NR2A antibodies play a role in the pathogenesis of NPSLE with seizure disorders.http://dx.doi.org/10.1155/2017/5047898 |
| spellingShingle | Yan Yang Chao Yuan Shu-qun Shen Xue-er Wang Qing-hua Mei Wen-qing Jiang Qin Huang Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus Mediators of Inflammation |
| title | Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus |
| title_full | Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus |
| title_fullStr | Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus |
| title_full_unstemmed | Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus |
| title_short | Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus |
| title_sort | autoantibodies to nr2a peptide of the glutamate nmda receptor in patients with seizure disorders in neuropsychiatric systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2017/5047898 |
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