In Search of a Function for BCLAF1
BCLAF1 was originally identified as a protein that interacts with antiapoptotic members of the Bcl2 family. Initial studies indicated a role for this protein as an inducer of apoptosis and repressor of transcription. Subsequent studies have shown that BCLAF1 plays criticals roles in a wide range of...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.132 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552312552292352 |
|---|---|
| author | Haya Sarras Solmaz Alizadeh Azami J. Peter McPherson |
| author_facet | Haya Sarras Solmaz Alizadeh Azami J. Peter McPherson |
| author_sort | Haya Sarras |
| collection | DOAJ |
| description | BCLAF1 was originally identified as a protein that interacts with antiapoptotic members of the Bcl2 family. Initial studies indicated a role for this protein as an inducer of apoptosis and repressor of transcription. Subsequent studies have shown that BCLAF1 plays criticals roles in a wide range of processes that are not normally associated with actions of Bcl2 family members, including lung development, T-cell activation, and control of the lytic infection program of Kaposi's sarcoma–associated herpesvirus. Here, we provide an overview of findings from past studies that both support and challenge the role of BCLAF1 in cell death and transcriptional control. We also present recent findings from our laboratory and others indicating a role for BCLAF1 in post-transcriptional processes that impact mRNA metabolism, instead of a direct role for this protein in apoptosis or transcription. |
| format | Article |
| id | doaj-art-a687b9045753417194100ea54d7b096c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a687b9045753417194100ea54d7b096c2025-02-03T05:59:02ZengWileyThe Scientific World Journal1537-744X2010-01-01101450146110.1100/tsw.2010.132In Search of a Function for BCLAF1Haya Sarras0Solmaz Alizadeh Azami1J. Peter McPherson2Department of Pharmacology and Toxicology, University of Toronto, CanadaDepartment of Pharmacology and Toxicology, University of Toronto, CanadaDepartment of Pharmacology and Toxicology, University of Toronto, CanadaBCLAF1 was originally identified as a protein that interacts with antiapoptotic members of the Bcl2 family. Initial studies indicated a role for this protein as an inducer of apoptosis and repressor of transcription. Subsequent studies have shown that BCLAF1 plays criticals roles in a wide range of processes that are not normally associated with actions of Bcl2 family members, including lung development, T-cell activation, and control of the lytic infection program of Kaposi's sarcoma–associated herpesvirus. Here, we provide an overview of findings from past studies that both support and challenge the role of BCLAF1 in cell death and transcriptional control. We also present recent findings from our laboratory and others indicating a role for BCLAF1 in post-transcriptional processes that impact mRNA metabolism, instead of a direct role for this protein in apoptosis or transcription.http://dx.doi.org/10.1100/tsw.2010.132 |
| spellingShingle | Haya Sarras Solmaz Alizadeh Azami J. Peter McPherson In Search of a Function for BCLAF1 The Scientific World Journal |
| title | In Search of a Function for BCLAF1 |
| title_full | In Search of a Function for BCLAF1 |
| title_fullStr | In Search of a Function for BCLAF1 |
| title_full_unstemmed | In Search of a Function for BCLAF1 |
| title_short | In Search of a Function for BCLAF1 |
| title_sort | in search of a function for bclaf1 |
| url | http://dx.doi.org/10.1100/tsw.2010.132 |
| work_keys_str_mv | AT hayasarras insearchofafunctionforbclaf1 AT solmazalizadehazami insearchofafunctionforbclaf1 AT jpetermcpherson insearchofafunctionforbclaf1 |