Development of Class IIa Bacteriocins as Therapeutic Agents
Class IIa bacteriocins have been primarily explored as natural food preservatives, but there is much interest in exploring the application of these peptides as therapeutic antimicrobial agents. Bacteriocins of this class possess antimicrobial activity against several important human pathogens. There...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2012/386410 |
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| _version_ | 1832555063560634368 |
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| author | Christopher T. Lohans John C. Vederas |
| author_facet | Christopher T. Lohans John C. Vederas |
| author_sort | Christopher T. Lohans |
| collection | DOAJ |
| description | Class IIa bacteriocins have been primarily explored as natural food preservatives, but there is much interest in exploring the application of these peptides as therapeutic antimicrobial agents. Bacteriocins of this class possess antimicrobial activity against several important human pathogens. Therefore, the therapeutic development of these bacteriocins will be reviewed. Biological and chemical modifications to both stabilize and increase the potency of bacteriocins are discussed, as well as the optimization of their production and purification. The suitability of bacteriocins as pharmaceuticals is explored through determinations of cytotoxicity, effects on the natural microbiota, and in vivo efficacy in mouse models. Recent results suggest that class IIa bacteriocins show promise as a class of therapeutic agents. |
| format | Article |
| id | doaj-art-a686b9cea07843d286dc88add949976c |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-a686b9cea07843d286dc88add949976c2025-02-03T05:49:40ZengWileyInternational Journal of Microbiology1687-918X1687-91982012-01-01201210.1155/2012/386410386410Development of Class IIa Bacteriocins as Therapeutic AgentsChristopher T. Lohans0John C. Vederas1Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, CanadaDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, CanadaClass IIa bacteriocins have been primarily explored as natural food preservatives, but there is much interest in exploring the application of these peptides as therapeutic antimicrobial agents. Bacteriocins of this class possess antimicrobial activity against several important human pathogens. Therefore, the therapeutic development of these bacteriocins will be reviewed. Biological and chemical modifications to both stabilize and increase the potency of bacteriocins are discussed, as well as the optimization of their production and purification. The suitability of bacteriocins as pharmaceuticals is explored through determinations of cytotoxicity, effects on the natural microbiota, and in vivo efficacy in mouse models. Recent results suggest that class IIa bacteriocins show promise as a class of therapeutic agents.http://dx.doi.org/10.1155/2012/386410 |
| spellingShingle | Christopher T. Lohans John C. Vederas Development of Class IIa Bacteriocins as Therapeutic Agents International Journal of Microbiology |
| title | Development of Class IIa Bacteriocins as Therapeutic Agents |
| title_full | Development of Class IIa Bacteriocins as Therapeutic Agents |
| title_fullStr | Development of Class IIa Bacteriocins as Therapeutic Agents |
| title_full_unstemmed | Development of Class IIa Bacteriocins as Therapeutic Agents |
| title_short | Development of Class IIa Bacteriocins as Therapeutic Agents |
| title_sort | development of class iia bacteriocins as therapeutic agents |
| url | http://dx.doi.org/10.1155/2012/386410 |
| work_keys_str_mv | AT christophertlohans developmentofclassiiabacteriocinsastherapeuticagents AT johncvederas developmentofclassiiabacteriocinsastherapeuticagents |