Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion
Prostate cancer is the most common malignancy found in North American and European men and the second most common cause of cancer related death. Since the practice of PSA screening has become common the disease is most often found early and can have a long indolent course. Current definitive therapy...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2016/4754031 |
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| author | M. Sean Peach Daniel M. Trifiletti Bruce Libby |
| author_facet | M. Sean Peach Daniel M. Trifiletti Bruce Libby |
| author_sort | M. Sean Peach |
| collection | DOAJ |
| description | Prostate cancer is the most common malignancy found in North American and European men and the second most common cause of cancer related death. Since the practice of PSA screening has become common the disease is most often found early and can have a long indolent course. Current definitive therapy treats the whole gland but has considerable long-term side effects. Focal therapies may be able to target the cancer while decreasing dose to organs at risk. Our objective was to determine if focal prostate brachytherapy could meet target objectives while permitting a decrease in dose to organs at risk in a way that would allow future salvage treatments. Further, we wanted to determine if focal treatment results in less toxicity. Utilizing the Medline repository, dosimetric papers comparing whole gland to partial gland brachytherapy and clinical papers that reported toxicity of focal brachytherapy were selected. A total of 9 dosimetric and 6 clinical papers met these inclusion criteria. Together, these manuscripts suggest that focal brachytherapy may be employed to decrease dose to organs at risk with decreased toxicity. Of current technology, image-guided HDR brachytherapy using MRI registered to transrectal ultrasound offers the flexibility and efficiency to achieve such focal treatments. |
| format | Article |
| id | doaj-art-a680e3a8d1c04f4a975517316b30acd1 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-a680e3a8d1c04f4a975517316b30acd12025-02-03T06:01:50ZengWileyProstate Cancer2090-31112090-312X2016-01-01201610.1155/2016/47540314754031Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound FusionM. Sean Peach0Daniel M. Trifiletti1Bruce Libby2Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA 22908, USADepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA 22908, USADepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA 22908, USAProstate cancer is the most common malignancy found in North American and European men and the second most common cause of cancer related death. Since the practice of PSA screening has become common the disease is most often found early and can have a long indolent course. Current definitive therapy treats the whole gland but has considerable long-term side effects. Focal therapies may be able to target the cancer while decreasing dose to organs at risk. Our objective was to determine if focal prostate brachytherapy could meet target objectives while permitting a decrease in dose to organs at risk in a way that would allow future salvage treatments. Further, we wanted to determine if focal treatment results in less toxicity. Utilizing the Medline repository, dosimetric papers comparing whole gland to partial gland brachytherapy and clinical papers that reported toxicity of focal brachytherapy were selected. A total of 9 dosimetric and 6 clinical papers met these inclusion criteria. Together, these manuscripts suggest that focal brachytherapy may be employed to decrease dose to organs at risk with decreased toxicity. Of current technology, image-guided HDR brachytherapy using MRI registered to transrectal ultrasound offers the flexibility and efficiency to achieve such focal treatments.http://dx.doi.org/10.1155/2016/4754031 |
| spellingShingle | M. Sean Peach Daniel M. Trifiletti Bruce Libby Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion Prostate Cancer |
| title | Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion |
| title_full | Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion |
| title_fullStr | Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion |
| title_full_unstemmed | Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion |
| title_short | Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion |
| title_sort | systematic review of focal prostate brachytherapy and the future implementation of image guided prostate hdr brachytherapy using mr ultrasound fusion |
| url | http://dx.doi.org/10.1155/2016/4754031 |
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