Yeast Methylotrophy: Metabolism, Gene Regulation and Peroxisome Homeostasis
Eukaryotic methylotrophs, which are able to obtain all the carbon and energy needed for growth from methanol, are restricted to a limited number of yeast species. When these yeasts are grown on methanol as the sole carbon and energy source, the enzymes involved in methanol metabolism are strongly i...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2011/101298 |
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| _version_ | 1832563172301602816 |
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| author | Hiroya Yurimoto Masahide Oku Yasuyoshi Sakai |
| author_facet | Hiroya Yurimoto Masahide Oku Yasuyoshi Sakai |
| author_sort | Hiroya Yurimoto |
| collection | DOAJ |
| description | Eukaryotic methylotrophs, which are able to obtain all the carbon and energy needed for growth from methanol, are restricted to a limited number of yeast species. When these yeasts are grown on methanol as the sole carbon and energy source, the enzymes involved in methanol metabolism are strongly induced, and the membrane-bound organelles, peroxisomes, which contain key enzymes of methanol metabolism, proliferate massively. These features have made methylotrophic yeasts attractive hosts for the production of heterologous proteins and useful model organisms for the study of peroxisome biogenesis and degradation. In this paper, we describe recent insights into the molecular basis of yeast methylotrophy. |
| format | Article |
| id | doaj-art-a6797b41b8b04372b0f479257d478c2d |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-a6797b41b8b04372b0f479257d478c2d2025-02-03T01:20:47ZengWileyInternational Journal of Microbiology1687-918X1687-91982011-01-01201110.1155/2011/101298101298Yeast Methylotrophy: Metabolism, Gene Regulation and Peroxisome HomeostasisHiroya Yurimoto0Masahide Oku1Yasuyoshi Sakai2Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa-Oiwake, Sakyo-ku, Kyoto 606-8502, JapanDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa-Oiwake, Sakyo-ku, Kyoto 606-8502, JapanDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa-Oiwake, Sakyo-ku, Kyoto 606-8502, JapanEukaryotic methylotrophs, which are able to obtain all the carbon and energy needed for growth from methanol, are restricted to a limited number of yeast species. When these yeasts are grown on methanol as the sole carbon and energy source, the enzymes involved in methanol metabolism are strongly induced, and the membrane-bound organelles, peroxisomes, which contain key enzymes of methanol metabolism, proliferate massively. These features have made methylotrophic yeasts attractive hosts for the production of heterologous proteins and useful model organisms for the study of peroxisome biogenesis and degradation. In this paper, we describe recent insights into the molecular basis of yeast methylotrophy.http://dx.doi.org/10.1155/2011/101298 |
| spellingShingle | Hiroya Yurimoto Masahide Oku Yasuyoshi Sakai Yeast Methylotrophy: Metabolism, Gene Regulation and Peroxisome Homeostasis International Journal of Microbiology |
| title | Yeast Methylotrophy: Metabolism, Gene Regulation and Peroxisome Homeostasis |
| title_full | Yeast Methylotrophy: Metabolism, Gene Regulation and Peroxisome Homeostasis |
| title_fullStr | Yeast Methylotrophy: Metabolism, Gene Regulation and Peroxisome Homeostasis |
| title_full_unstemmed | Yeast Methylotrophy: Metabolism, Gene Regulation and Peroxisome Homeostasis |
| title_short | Yeast Methylotrophy: Metabolism, Gene Regulation and Peroxisome Homeostasis |
| title_sort | yeast methylotrophy metabolism gene regulation and peroxisome homeostasis |
| url | http://dx.doi.org/10.1155/2011/101298 |
| work_keys_str_mv | AT hiroyayurimoto yeastmethylotrophymetabolismgeneregulationandperoxisomehomeostasis AT masahideoku yeastmethylotrophymetabolismgeneregulationandperoxisomehomeostasis AT yasuyoshisakai yeastmethylotrophymetabolismgeneregulationandperoxisomehomeostasis |