IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.

IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.

<h4>Background</h4>Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly...

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Main Authors: Fernando M Botelho, Carla M T Bauer, Donna Finch, Jake K Nikota, Caleb C J Zavitz, Ashling Kelly, Kristen N Lambert, Sian Piper, Martyn L Foster, James J P Goldring, Jadwiga A Wedzicha, Jennifer Bassett, Jonathan Bramson, Yoichiro Iwakura, Matthew Sleeman, Roland Kolbeck, Anthony J Coyle, Alison A Humbles, Martin R Stämpfli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028457&type=printable
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