Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline
2-Chloro-3-methylquinoxaline was selected as nucleus around which the molecular manipulations were carried out to get new compounds expected to possess better anti microbial activity. Various quinoxaline derivatives have been synthesized by replacing the chlorine at C-2 with a thioether linkage, whi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/482831 |
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| author | D. C. P. Singh S. R. Hashim R. G. Singhal |
| author_facet | D. C. P. Singh S. R. Hashim R. G. Singhal |
| author_sort | D. C. P. Singh |
| collection | DOAJ |
| description | 2-Chloro-3-methylquinoxaline was selected as nucleus around which the molecular manipulations were carried out to get new compounds expected to possess better anti microbial activity. Various quinoxaline derivatives have been synthesized by replacing the chlorine at C-2 with a thioether linkage, which in turn attached to 2-(N-(substituted phenyl)acetamides. The synthesized compounds (5) were tested for their antimicrobial activity. Compounds 5b, 5c, 5d and 5i were found most active (comparable to the standard antibacterial Ciprofloxacin) amongst them. The structure of the compounds was confirmed on the basis of their spectral data. |
| format | Article |
| id | doaj-art-a663712e2c7e4364b573f769bc2f26bf |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-a663712e2c7e4364b573f769bc2f26bf2025-02-03T06:11:30ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018263564210.1155/2011/482831Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of QuinoxalineD. C. P. Singh0S. R. Hashim1R. G. Singhal2Department of Pharmaceutical Chemistry College of Pharmacy, Institute of Foreign Trade and Management, Moradabad-244001, IndiaDepartment of Pharmaceutical Chemistry College of Pharmacy, Institute of Foreign Trade and Management, Moradabad-244001, IndiaSchool of Pharmaceutical Sciences Shobhit University, Meerut, India2-Chloro-3-methylquinoxaline was selected as nucleus around which the molecular manipulations were carried out to get new compounds expected to possess better anti microbial activity. Various quinoxaline derivatives have been synthesized by replacing the chlorine at C-2 with a thioether linkage, which in turn attached to 2-(N-(substituted phenyl)acetamides. The synthesized compounds (5) were tested for their antimicrobial activity. Compounds 5b, 5c, 5d and 5i were found most active (comparable to the standard antibacterial Ciprofloxacin) amongst them. The structure of the compounds was confirmed on the basis of their spectral data.http://dx.doi.org/10.1155/2011/482831 |
| spellingShingle | D. C. P. Singh S. R. Hashim R. G. Singhal Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline E-Journal of Chemistry |
| title | Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline |
| title_full | Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline |
| title_fullStr | Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline |
| title_full_unstemmed | Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline |
| title_short | Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline |
| title_sort | synthesis and antimicrobial activity ofsome new thioether derivatives of quinoxaline |
| url | http://dx.doi.org/10.1155/2011/482831 |
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