Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China
BackgroundThis study aimed to investigate the relationship between urinary fluoride concentration and myocardial disease.MethodsThis is a cross-sectional study that was conducted in three villages in Wenshui County, Shanxi Province. A total of 737 villagers were included in this analysis. Urinary fl...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1410056/full |
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| author | Junhua Wu Ming Qin Yue Gao Yang Liu Xiaona Liu Yuting Jiang Yanmei Yang Yanhui Gao |
| author_facet | Junhua Wu Ming Qin Yue Gao Yang Liu Xiaona Liu Yuting Jiang Yanmei Yang Yanhui Gao |
| author_sort | Junhua Wu |
| collection | DOAJ |
| description | BackgroundThis study aimed to investigate the relationship between urinary fluoride concentration and myocardial disease.MethodsThis is a cross-sectional study that was conducted in three villages in Wenshui County, Shanxi Province. A total of 737 villagers were included in this analysis. Urinary fluoride was detected using a fluoride-ion selective electrode. Myocardial enzymes were detected using an automatic biochemical analyzer. Myocardial ischemia and arrhythmia were diagnosed using 12-lead electrocardiogram.ResultsThe median level of urinary fluoride concentration was 1.32 mg/L. Urinary fluoride was associated with serum creatine kinase (CK) elevation (odds ratio [OR] = 1.39 [95% confidence interval (CI)]: 1.09–1.78) and CK isoenzyme (CK-MB) elevation (OR = 1.49 [95% CI: 1.12–1.97]). Stratified analysis revealed that urinary fluoride concentration was associated with CK elevation in villagers under the age of 60 years (OR = 1.80 [95% CI: 1.26–2.59]). This study found that there was a positive association between urinary fluoride concentration and the risk of CK-MB elevation in participants under the age of 60 years(OR = 2.18 [95% CI: 1.39–3.42]), those who were of female gender (OR = 1.53 [95% CI: 1.07–2.19]), those who were overweight/obese (OR = 1.96 [95% CI: 1.28–2.99]), those who had central obesity (OR = 1.59 [95% CI: 1.12–2.25]), consumed alcohol (OR = 1.49 [95% CI: 1.09–2.05]), and smoked (OR = 1.50 [95% CI: 1.10–2.04]).ConclusionOur study suggests that fluoride exposure is associated with the risk of serum CK and CK-MB elevation; however, it is not associated with myocardial ischemia, arrhythmia, serum lactate dehydrogenase (LDH), serum alpha-hydroxybutyrate dehydrogenase (α-HBD), or serum aspartate aminotransferase (AST). Further investigations are needed to substantiate our findings and explore the potential underlying mechanisms. |
| format | Article |
| id | doaj-art-a661575780b74e118b89427a93fa10e3 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-a661575780b74e118b89427a93fa10e32025-01-29T19:18:34ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011210.3389/fpubh.2024.14100561410056Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in ChinaJunhua WuMing QinYue GaoYang LiuXiaona LiuYuting JiangYanmei YangYanhui GaoBackgroundThis study aimed to investigate the relationship between urinary fluoride concentration and myocardial disease.MethodsThis is a cross-sectional study that was conducted in three villages in Wenshui County, Shanxi Province. A total of 737 villagers were included in this analysis. Urinary fluoride was detected using a fluoride-ion selective electrode. Myocardial enzymes were detected using an automatic biochemical analyzer. Myocardial ischemia and arrhythmia were diagnosed using 12-lead electrocardiogram.ResultsThe median level of urinary fluoride concentration was 1.32 mg/L. Urinary fluoride was associated with serum creatine kinase (CK) elevation (odds ratio [OR] = 1.39 [95% confidence interval (CI)]: 1.09–1.78) and CK isoenzyme (CK-MB) elevation (OR = 1.49 [95% CI: 1.12–1.97]). Stratified analysis revealed that urinary fluoride concentration was associated with CK elevation in villagers under the age of 60 years (OR = 1.80 [95% CI: 1.26–2.59]). This study found that there was a positive association between urinary fluoride concentration and the risk of CK-MB elevation in participants under the age of 60 years(OR = 2.18 [95% CI: 1.39–3.42]), those who were of female gender (OR = 1.53 [95% CI: 1.07–2.19]), those who were overweight/obese (OR = 1.96 [95% CI: 1.28–2.99]), those who had central obesity (OR = 1.59 [95% CI: 1.12–2.25]), consumed alcohol (OR = 1.49 [95% CI: 1.09–2.05]), and smoked (OR = 1.50 [95% CI: 1.10–2.04]).ConclusionOur study suggests that fluoride exposure is associated with the risk of serum CK and CK-MB elevation; however, it is not associated with myocardial ischemia, arrhythmia, serum lactate dehydrogenase (LDH), serum alpha-hydroxybutyrate dehydrogenase (α-HBD), or serum aspartate aminotransferase (AST). Further investigations are needed to substantiate our findings and explore the potential underlying mechanisms.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1410056/fullcreatine kinasecreatine kinase isoenzymefluoridemyocardial ischemiaarrhythmia |
| spellingShingle | Junhua Wu Ming Qin Yue Gao Yang Liu Xiaona Liu Yuting Jiang Yanmei Yang Yanhui Gao Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China Frontiers in Public Health creatine kinase creatine kinase isoenzyme fluoride myocardial ischemia arrhythmia |
| title | Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China |
| title_full | Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China |
| title_fullStr | Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China |
| title_full_unstemmed | Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China |
| title_short | Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China |
| title_sort | association between fluoride exposure and the risk of serum ck and ck mb elevation in adults a cross sectional study in china |
| topic | creatine kinase creatine kinase isoenzyme fluoride myocardial ischemia arrhythmia |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1410056/full |
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