Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa

Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa

ABSTRACT The ftsI locus of gram-negative bacteria encodes penicillin-binding protein 3 (PBP3), a common target of β-lactam antibiotics. Recent genomic surveillance of carbapenem-resistant Pseudomonas aeruginosa revealed that 17% of strains possessed nonsynonymous substitution in ftsI. However, the c...

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Bibliographic Details
Main Authors: Hirokazu Yano, Noboru Nakata, Koji Yahara, Motoyuki Sugai, Yukari Sato
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
penicillin-binding protein
PBP3
FtsI
carbapenem-resistant Pseudomonas aeruginosa
doripenem
meropenem
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01027-25
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