Prognostic and Diagnostic Value of Endocan in Kidney Diseases
Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovasculari...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2022/3861092 |
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| _version_ | 1832564905583050752 |
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| author | Elisabeth Samouilidou Virginia Athanasiadou Eirini Grapsa |
| author_facet | Elisabeth Samouilidou Virginia Athanasiadou Eirini Grapsa |
| author_sort | Elisabeth Samouilidou |
| collection | DOAJ |
| description | Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovascularization processes. The utility of endocan as a biomarker in a wide spectrum of diseases is being increasingly acknowledged. In this review, we summarize the current evidence concerning the role of endocan in kidney diseases, with emphasis on its prognostic and diagnostic value. It seems that the determination of plasma endocan levels may provide useful prognostic information in many types of renal failure such as chronic kidney disease, IgA nephropathy, and diabetic nephropathy. Endocan could additionally improve the early diagnostic evaluation of acute kidney disease, chronic renal allograft injury, and acute rejection after kidney transplantation, thus contributing to endothelial cell injury monitoring in a timely manner. |
| format | Article |
| id | doaj-art-a656f9667936478c964b6392b54aa6dc |
| institution | Kabale University |
| issn | 2090-2158 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-a656f9667936478c964b6392b54aa6dc2025-02-03T01:10:00ZengWileyInternational Journal of Nephrology2090-21582022-01-01202210.1155/2022/3861092Prognostic and Diagnostic Value of Endocan in Kidney DiseasesElisabeth Samouilidou0Virginia Athanasiadou1Eirini Grapsa2Department of BiochemistryRenal UnitRenal UnitEndocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovascularization processes. The utility of endocan as a biomarker in a wide spectrum of diseases is being increasingly acknowledged. In this review, we summarize the current evidence concerning the role of endocan in kidney diseases, with emphasis on its prognostic and diagnostic value. It seems that the determination of plasma endocan levels may provide useful prognostic information in many types of renal failure such as chronic kidney disease, IgA nephropathy, and diabetic nephropathy. Endocan could additionally improve the early diagnostic evaluation of acute kidney disease, chronic renal allograft injury, and acute rejection after kidney transplantation, thus contributing to endothelial cell injury monitoring in a timely manner.http://dx.doi.org/10.1155/2022/3861092 |
| spellingShingle | Elisabeth Samouilidou Virginia Athanasiadou Eirini Grapsa Prognostic and Diagnostic Value of Endocan in Kidney Diseases International Journal of Nephrology |
| title | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
| title_full | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
| title_fullStr | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
| title_full_unstemmed | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
| title_short | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
| title_sort | prognostic and diagnostic value of endocan in kidney diseases |
| url | http://dx.doi.org/10.1155/2022/3861092 |
| work_keys_str_mv | AT elisabethsamouilidou prognosticanddiagnosticvalueofendocaninkidneydiseases AT virginiaathanasiadou prognosticanddiagnosticvalueofendocaninkidneydiseases AT eirinigrapsa prognosticanddiagnosticvalueofendocaninkidneydiseases |