Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An Insight from the China H-Type Hypertension Registry Study
Background. Previous studies have revealed the triglyceride-glucose (TyG) index is closely related to hyperuricemia in the general population. However, this relationship in hypertensive patients has not been reported. The aims of this study are to investigate the relationship of the TyG index and hy...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/4272715 |
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| author | Chao Yu Tao Wang Wei Zhou Lingjuan Zhu Xiao Huang Huihui Bao Xiaoshu Cheng |
| author_facet | Chao Yu Tao Wang Wei Zhou Lingjuan Zhu Xiao Huang Huihui Bao Xiaoshu Cheng |
| author_sort | Chao Yu |
| collection | DOAJ |
| description | Background. Previous studies have revealed the triglyceride-glucose (TyG) index is closely related to hyperuricemia in the general population. However, this relationship in hypertensive patients has not been reported. The aims of this study are to investigate the relationship of the TyG index and hyperuricemia in adult Chinese hypertension. Methods. The China H-type Hypertension Registration (an observational, noninterventional, and real-world study) was conducted from March 01, 2018, to August 31, 2018, in 16 communities in Wuyuan of China. The TyG index was calculated from fasting triglycerides (mg/dL) and fasting glucose (mg/dL)/2. Hyperuricemia was categorized by uric acid concentration ≥420 μmol/L (7 mg/dL). Results. Overall average TyG index of 13,060 adults with hypertension was 8.87; age was 63.81 years. The TyG index was positively correlated with serum uric acid by multiple linear regression analyses (β = 38.03; 95% CI: 34.55 to 41.51). Coincidentally, logistic analyses also demonstrated the TyG index had a positive correlation with hyperuricemia (OR = 2.04; 95% CI: 1.87 to 2.24). Strong linear associations of the TyG index with serum uric acid and hyperuricemia were confirmed by restricted cubic spline analysis. Compared with subjects in the lowest quartile (7.13 to 8.44) of the TyG index, subjects in the 2nd–4th quartiles had 1.25 (95% CI: 1.10 to 1.41), 1.63 (95% CI: 1.43 to 1.86), and 2.79 (95% CI: 2.41 to 3.24) times greater incident risk of developing hyperuricemia. The TyG index had significant correlations between male patients and hyperuricemia (OR = 2.01) by subgroup analysis. Conclusion. Positive associations were found between the TyG index and serum uric acid and between the TyG index and hyperuricemia in adults with hypertension. This trial was registered at clinicaltrials.gov as ChiCTR1800017274. |
| format | Article |
| id | doaj-art-a65651f187bd4033913f34c0cf53243c |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a65651f187bd4033913f34c0cf53243c2025-02-03T01:07:11ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/4272715Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An Insight from the China H-Type Hypertension Registry StudyChao Yu0Tao Wang1Wei Zhou2Lingjuan Zhu3Xiao Huang4Huihui Bao5Xiaoshu Cheng6Center for Prevention and Treatment of Cardiovascular DiseasesCenter for Prevention and Treatment of Cardiovascular DiseasesCenter for Prevention and Treatment of Cardiovascular DiseasesCenter for Prevention and Treatment of Cardiovascular DiseasesCenter for Prevention and Treatment of Cardiovascular DiseasesCenter for Prevention and Treatment of Cardiovascular DiseasesCenter for Prevention and Treatment of Cardiovascular DiseasesBackground. Previous studies have revealed the triglyceride-glucose (TyG) index is closely related to hyperuricemia in the general population. However, this relationship in hypertensive patients has not been reported. The aims of this study are to investigate the relationship of the TyG index and hyperuricemia in adult Chinese hypertension. Methods. The China H-type Hypertension Registration (an observational, noninterventional, and real-world study) was conducted from March 01, 2018, to August 31, 2018, in 16 communities in Wuyuan of China. The TyG index was calculated from fasting triglycerides (mg/dL) and fasting glucose (mg/dL)/2. Hyperuricemia was categorized by uric acid concentration ≥420 μmol/L (7 mg/dL). Results. Overall average TyG index of 13,060 adults with hypertension was 8.87; age was 63.81 years. The TyG index was positively correlated with serum uric acid by multiple linear regression analyses (β = 38.03; 95% CI: 34.55 to 41.51). Coincidentally, logistic analyses also demonstrated the TyG index had a positive correlation with hyperuricemia (OR = 2.04; 95% CI: 1.87 to 2.24). Strong linear associations of the TyG index with serum uric acid and hyperuricemia were confirmed by restricted cubic spline analysis. Compared with subjects in the lowest quartile (7.13 to 8.44) of the TyG index, subjects in the 2nd–4th quartiles had 1.25 (95% CI: 1.10 to 1.41), 1.63 (95% CI: 1.43 to 1.86), and 2.79 (95% CI: 2.41 to 3.24) times greater incident risk of developing hyperuricemia. The TyG index had significant correlations between male patients and hyperuricemia (OR = 2.01) by subgroup analysis. Conclusion. Positive associations were found between the TyG index and serum uric acid and between the TyG index and hyperuricemia in adults with hypertension. This trial was registered at clinicaltrials.gov as ChiCTR1800017274.http://dx.doi.org/10.1155/2022/4272715 |
| spellingShingle | Chao Yu Tao Wang Wei Zhou Lingjuan Zhu Xiao Huang Huihui Bao Xiaoshu Cheng Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An Insight from the China H-Type Hypertension Registry Study International Journal of Endocrinology |
| title | Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An Insight from the China H-Type Hypertension Registry Study |
| title_full | Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An Insight from the China H-Type Hypertension Registry Study |
| title_fullStr | Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An Insight from the China H-Type Hypertension Registry Study |
| title_full_unstemmed | Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An Insight from the China H-Type Hypertension Registry Study |
| title_short | Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An Insight from the China H-Type Hypertension Registry Study |
| title_sort | positive association between the triglyceride glucose index and hyperuricemia in chinese adults with hypertension an insight from the china h type hypertension registry study |
| url | http://dx.doi.org/10.1155/2022/4272715 |
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