Green and sustainable LC-APCI-MS/MS method for simultaneous quantification of genotoxic nitrosamines in antidiabetic medication: sitagliptin

Green and sustainable LC-APCI-MS/MS method for simultaneous quantification of genotoxic nitrosamines in antidiabetic medication: sitagliptin

Abstract The International Agency for Research on Cancer categorized nitrosamines as potential or probable human carcinogens. Hence, nitrosamine impurities should be controlled to minimize the cancer risk. Sustainable Development Goal 9 (SDG9: Industry, Innovation, and Infrastructure), Target 9.4 wa...

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Bibliographic Details
Main Authors: Sriram Pepakayala, Venkata Nadh Ratnakaram, Yuvaraj Zunjarrao, Yogesh Kumar Lohia
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Chemistry
Subjects:
Nitrosamines
Genotoxic impurities
LC–MS/MS
Method development
Multiple reaction monitoring
Validation
Online Access:https://doi.org/10.1186/s13065-025-01503-4
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